妊娠期糖尿病对后代哮喘风险的影响。

The effect of gestational diabetes mellitus on the risk of asthma in offspring.

机构信息

Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.

出版信息

Ann Epidemiol. 2021 May;57:7-13. doi: 10.1016/j.annepidem.2021.02.003. Epub 2021 Feb 14.

DOI:10.1016/j.annepidem.2021.02.003

PMID:33596445

Abstract

PURPOSE

To examine the effect of maternal gestational diabetes mellitus on the risk of asthma in the offspring.

METHODS

This cohort study used data from 19,933 children in the National Longitudinal Survey of Children and Youth (NLSCY), 1994/1995-2008/2009, Canada. Children were followed until the first-time report of having health professional-diagnosed asthma (hereafter incident asthma), loss to follow-up, or end of the NLSCY follow-up, whichever occurred first. As a surrogate for Cox proportional hazards regression, pooled logistic regression models, crude and adjusted for potential confounders, were fitted to estimate the effect of gestational diabetes mellitus on the risk of asthma in the offspring.

RESULTS

Among the 19,933 children, 1,178 (5.9%) had mothers with gestational diabetes mellitus. The median duration of follow-up was 4 (interquartile range: 4) years. A total of 1639 children in the cohort had reported incident asthma during the follow-up, and 119 of them had mothers with gestational diabetes mellitus. The adjusted hazard ratio for the association between gestational diabetes mellitus and incident asthma in offspring was 1.25 (95% confidence interval [CI] 1.03, 1.51).

CONCLUSIONS

Our findings suggest that gestational diabetes mellitus increases the risk of asthma in the offspring.

摘要

目的

探讨母亲妊娠期糖尿病对后代哮喘发病风险的影响。

方法

本队列研究使用了加拿大 1994/1995 年至 2008/2009 年全国儿童纵向调查（NLSCY）中 19933 名儿童的数据。对儿童进行随访，直至首次报告有健康专业人员诊断的哮喘（以下简称新发哮喘）、失访或 NLSCY 随访结束，以先发生者为准。作为 Cox 比例风险回归的替代方法，采用汇总逻辑回归模型，对未调整和调整潜在混杂因素后的模型进行拟合，以估计母亲妊娠期糖尿病对后代哮喘发病风险的影响。

结果

在 19933 名儿童中，有 1178 名（5.9%）的母亲患有妊娠期糖尿病。中位随访时间为 4 年（四分位距：4 年）。在随访期间，共有 1639 名儿童报告发生新发哮喘，其中 119 名儿童的母亲患有妊娠期糖尿病。妊娠期糖尿病与后代新发哮喘之间的关联调整后危险比为 1.25（95%置信区间 [CI] 1.03，1.51）。