Department of Toxicology, School of Public Health, Guangxi Medical University, No. 22, Shuang-yong Rd, Nanning, 530021, Guangxi, China; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, China.
Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Food Chem Toxicol. 2021 Apr;150:112063. doi: 10.1016/j.fct.2021.112063. Epub 2021 Feb 14.
Lead is a heavy metal pollutant that is widely present in the environment. It affects every organ system, yet the nervous system appears to be the most sensitive and primary target. Although many countries have made significant strides in controlling Pb pollution, Pb poisoning continuous to be a major public health concern. Exposure to Pb causes neurotoxicity that ranges from neurodevelopmental disorders to severe neurodegenerative lesions, leading to impairments in learning, memory, and cognitive function. Studies on the mechanisms of Pb-induced nervous system injury have convincingly shown that this metal can affect a plethora of cellular pathways affecting on cell survival, altering calcium dyshomeostasis, and inducing apoptosis, inflammation, energy metabolism disorders, oxidative stress, autophagy and glial stress. This review summarizes recent knowledge on multiple signaling pathways associated with Pb-induced neurological disorders in vivo and in vitro.
铅是一种广泛存在于环境中的重金属污染物。它影响着每一个器官系统，但神经系统似乎是最敏感和主要的靶器官。尽管许多国家在控制铅污染方面取得了重大进展，但铅中毒仍然是一个主要的公共卫生问题。铅暴露会导致神经毒性，从神经发育障碍到严重的神经退行性病变，导致学习、记忆和认知功能受损。铅诱导的神经系统损伤机制的研究令人信服地表明，这种金属可以影响许多影响细胞存活的细胞途径，改变钙稳态失衡，并诱导细胞凋亡、炎症、能量代谢紊乱、氧化应激、自噬和神经胶质应激。本综述总结了近年来关于体内和体外铅诱导神经紊乱相关的多种信号通路的知识。
