Department of Obstetrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University Guangzhou, Guangzhou, China.
Department of Obstetrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University Guangzhou, Guangzhou, China,
Gynecol Obstet Invest. 2021;86(1-2):88-93. doi: 10.1159/000512460. Epub 2021 Feb 17.
Parturition involves multiple complex metabolic processes that supply essential metabolites to facilitate fetal delivery. Little is known about the dynamic metabolic responses during labor.
To profile the changes of myometrial metabolites between nonlabor and labor.
The study involved 30 women in nonlabor and 30 in labor who underwent cesarean section. The characteristics of myometrial metabolite changes during parturition were explored through untargeted metabolomic analysis. Data were analyzed by multivariate and univariate statistical analysis.
Partial least squares-discriminant analysis plots significantly differentiated between the groups. In total, 392 metabolites were significantly distinct between the groups, among which lipid molecules were predominant. A 75% increase in fatty acids, 67% increase in fatty acid carnitines, 66% increase in glycerophospholipids, 83% increase in mono- and diacylglycerols, and 67% decrease in triacyclglycerols were observed in the patients during labor. Most glucose, amino acid, and steroid hormone metabolism also slightly increased in labor.
An increase in lipolysis, fatty acid oxidation, amino acid catabolism, and steroid hormone metabolism was observed during parturition. The change of lipolysis and fatty acid oxidation is the most significant.
分娩涉及多个复杂的代谢过程，这些过程提供必需的代谢物以促进胎儿分娩。对于分娩过程中的动态代谢反应，人们知之甚少。
分析非分娩期和分娩期子宫肌层代谢物的变化特征。
本研究纳入 30 例非分娩和 30 例剖宫产的产妇。通过非靶向代谢组学分析探讨分娩过程中子宫肌层代谢物变化的特征。采用多元和单变量统计分析对数据进行分析。
偏最小二乘判别分析图明显区分了两组。总共发现 392 种代谢物在两组间有显著差异，其中脂质分子占主导地位。与非分娩期相比，分娩期的脂肪酸增加了 75%，脂肪酸肉碱增加了 67%，甘油磷脂增加了 66%，单、二酰基甘油增加了 83%，三酰基甘油减少了 67%。大多数葡萄糖、氨基酸和甾体激素代谢物在分娩时也略有增加。
分娩过程中观察到脂肪分解、脂肪酸氧化、氨基酸分解代谢和甾体激素代谢增加。脂肪分解和脂肪酸氧化的变化最为显著。
