Kamitsuji H, Matsunaga K, Taira K, Nakajima M, Whitworth J A, Kincaid-Smith P
Department of Paediatrics, Nara Medical College, Japan.
Clin Nephrol. 1988 Mar;29(3):124-8.
The concentration of cross-linked fibrin degradation products (XLFDP) in urine were determined by enzyme-linked immunosorbent assay (ELISA) or radioimmunoassay (RIA) in patients with several types of glomerulonephritis with crescents (CrGN). In patients with "active" cellular crescents, increased levels of XLFDP correlated with the percentage of glomeruli containing crescents. Dysmorphic erythrocytes, suggestive of glomerular bleeding, were observed in all of the patients with CrGN, and the urinary red cell counts (URCC) also correlated with percentage of glomeruli containing crescents. The absence of correlation between urinary XLFDP and URCC or urinary protein suggested that lysis of fibrin within crescents may contribute to the urinary excretion of XLFDP in CrGN. The measurement of urinary XLFDP in CrGN is likely to be of value in assessing the activity of glomerular lesions but not renal function.
采用酶联免疫吸附测定（ELISA）或放射免疫测定（RIA）法，对几种类型的新月体性肾小球肾炎（CrGN）患者尿液中的交联纤维蛋白降解产物（XLFDP）浓度进行了测定。在患有“活动性”细胞性新月体的患者中，XLFDP水平升高与含有新月体的肾小球百分比相关。在所有CrGN患者中均观察到提示肾小球出血的畸形红细胞，尿红细胞计数（URCC）也与含有新月体的肾小球百分比相关。尿XLFDP与URCC或尿蛋白之间缺乏相关性，提示新月体内纤维蛋白的溶解可能有助于CrGN患者尿液中XLFDP的排泄。测定CrGN患者尿液中的XLFDP可能对评估肾小球病变的活动性有价值，但对评估肾功能无价值。
