Hatano Satoshi, Yamamoto Eisuke, Toyomasu Yoshitaka, Ishiguro Toru, Kumagai Yoichi, Ishibashi Keiichiro, Mochiki Erito, Ishida Hideyuki, Suzuki Shinichi
Dept. of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University.
Gan To Kagaku Ryoho. 2021 Feb;48(2):236-238.
Familial adenomatous polyposis(FAP)is an autosomal dominantly inherited disorder, and the result of a germ line variant in the adenomatous poplyposis coli(APC)gene. FAP can be associated with various extracolonic lesions including thyroid cancer, which frequently occurs in women. We report the case of a 15-year-old woman diagnosed as FAP with multiple thyroid papillary carcinomas. Her mother had been treated for FAP with colorectal cancer and thyroid cancer in our department. Multiple tumors with a maximum diameter of 17 mm were detected in the right lobe of the thyroid gland during the preoperative examination. Papillary carcinoma was suspected based on fine-needle aspiration cytology. She was diagnosed with FAP because of multiple polyps on colonoscopy. We performed a subtotal thyroidectomy. Pathological findings revealed a cribriform-morular variant of papillary thyroid carcinoma. We report a rare case of papillary carcinoma of thyroid associated with FAP in a younger woman.
家族性腺瘤性息肉病（FAP）是一种常染色体显性遗传性疾病，是腺瘤性息肉病 coli（APC）基因种系变异的结果。FAP 可伴有各种结肠外病变，包括甲状腺癌，甲状腺癌在女性中经常发生。我们报告了一例 15 岁被诊断为 FAP 并患有多发性甲状腺乳头状癌的女性病例。她的母亲曾在我们科室因 FAP 伴结直肠癌和甲状腺癌接受治疗。术前检查时在甲状腺右叶发现多个最大直径为 17 毫米的肿瘤。根据细针穿刺细胞学检查怀疑为乳头状癌。因结肠镜检查发现多发息肉，她被诊断为 FAP。我们进行了甲状腺次全切除术。病理结果显示为甲状腺乳头状癌的筛状-桑葚状变异型。我们报告了一例年轻女性中罕见的与 FAP 相关的甲状腺乳头状癌病例。
