Rovina Rafael L, da Rocha Alisson L, Marafon Bruno B, Pauli José R, de Moura Leandro P, Cintra Dennys E, Ropelle Eduardo R, da Silva Adelino S R
School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, Brazil.
Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, Brazil.
Front Physiol. 2021 Feb 1;12:626096. doi: 10.3389/fphys.2021.626096. eCollection 2021.
The nuclear receptor subfamily 1, group D member 1 (, plays a role in the skeletal muscle's oxidative capacity, mitochondrial biogenesis, atrophy genes, and muscle fiber size. In light of the effects of physical exercise, the present study investigates the acute response of and genes related to atrophy and mitochondrial biogenesis on endurance and resistance exercise protocols. In this investigation, we observed, after one bout of endurance exercise, an upregulation of in soleus muscle, but not in the gastrocnemius, and some genes related to mitochondrial biogenesis and atrophy were enhanced as well. Also, analysis of muscle transcripts from diverse isogenic BXD mice families revealed that the strains with higher gene expression displayed upregulation of AMPK signaling and mitochondrial-related genes. In summary, a single session of endurance exercise can enhance the mRNA levels in an oxidative muscle.
核受体亚家族1 D组成员1（在骨骼肌的氧化能力、线粒体生物发生、萎缩基因和肌纤维大小方面发挥作用。鉴于体育锻炼的影响，本研究调查了该基因以及与萎缩和线粒体生物发生相关的基因对耐力和阻力运动方案的急性反应。在这项研究中，我们观察到，单次耐力运动后，比目鱼肌中的该基因上调，但腓肠肌中未上调，并且一些与线粒体生物发生和萎缩相关的基因也得到增强。此外，对来自不同同基因BXD小鼠家族的肌肉转录本分析表明，该基因表达较高的品系中AMPK信号通路和线粒体相关基因上调。总之，单次耐力运动可以提高氧化型肌肉中该基因的mRNA水平。
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