Brown C G, Taylor R B, Werman H A, Luu T, Spittler G, Hamlin R L
Division of Emergency Medicine, Ohio State University, Columbus 43210.
Crit Care Med. 1988 May;16(5):536-9. doi: 10.1097/00003246-198805000-00013.
This preliminary study was conducted to evaluate the effects of 0.02 mg/kg of epinephrine (E) on myocardial blood flow (MBF), myocardial oxygen consumption (MVO2), and delivery (MDO2) when administered during CPR after 10-min cardiopulmonary arrest. Five miniature swine were instrumented for MBF measurements using tracer microspheres. Ventricular fibrillation was induced. After 10 min, CPR was begun with a pneumatic compressor. Measurements of MBF, arterial, and coronary sinus blood gases were made. After 3 min of CPR, each animal received 0.02 mg/kg of E. The measurements were repeated and defibrillation was attempted. During CPR, MDO2 and MVO2 were 0.2 +/- 0.3 and 0.2 +/- 0.3 ml/min/100 g tissue, respectively. The myocardial oxygen extraction ratio (ER) was 94.2 +/- 3.0%. After 0.02 mg/kg of E, MDO2 was 1.1 +/- 1.4, MVO2 was 1.0 +/- 1.3, and ER was 93.9 +/- 0.7% (p greater than .05). There were no successful defibrillations. These data indicate that MDO2 improves slightly during CPR after 0.02 mg/kg of E, but it does not meet the oxygen demands of the fibrillating heart.
本初步研究旨在评估在心肺骤停10分钟后进行心肺复苏（CPR）期间给予0.02mg/kg肾上腺素（E）对心肌血流量（MBF）、心肌耗氧量（MVO2）和心肌氧输送量（MDO2）的影响。使用示踪微球对5只小型猪进行仪器安装以测量MBF。诱发室颤。10分钟后，使用气动压缩机开始进行CPR。测量MBF、动脉血和冠状窦血气。CPR 3分钟后，每只动物接受0.02mg/kg的E。重复测量并尝试除颤。在CPR期间，MDO2和MVO2分别为0.2±0.3和0.2±0.3ml/min/100g组织。心肌氧摄取率（ER）为94.2±3.0%。给予0.02mg/kg的E后，MDO2为1.1±1.4，MVO2为1.0±1.3，ER为93.9±0.7%（p＞0.05）。未成功除颤。这些数据表明，给予0.02mg/kg的E后，CPR期间MDO2略有改善，但未满足颤动心脏的氧需求。
