Sabri Mohammad Reza, Mahdavi Chehreh, Bigdelian Hamid, Ahmadi Ali Reza, Ghaderian Mehdi, Dehghan Bahar
Professor, Pediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Assistant Professor, Pediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
ARYA Atheroscler. 2020 Jul;16(4):208-210. doi: 10.22122/arya.v16i4.2157.
Atrial septal defect (ASD) is one of the most common congenital heart defects (CHDs) with prevalence of 8% to 10% in children with CHD and incidence of 56 per 100000 live births. It is categorized according to the defect site in which the most common form is secundum ASD (ASD2) with the defect in the central part of the atrial septum.
In our case series, we evaluated five children aged under one year old with ASD2 and pulmonary hypertension (PH). All the patients were referred for surgical ASD closure. Their PH was improved and the size of right atrium (RA) and right ventricle (RV) became normal during the follow-up and one year after the surgery all of them had normal pulmonary artery pressure (PAP) with normal RA and RV size.
According to our study and those done by others, the prevalence of PH in infants with ASD is low, but when this combination is found without any other CHD, ASD closure should be considered.
房间隔缺损（ASD）是最常见的先天性心脏病（CHD）之一，在患有CHD的儿童中患病率为8%至10%，每10万例活产儿中的发病率为56例。它根据缺损部位进行分类，其中最常见的类型是继发孔型房间隔缺损（ASD2），缺损位于房间隔的中央部分。
在我们的病例系列中，我们评估了5名1岁以下患有ASD2和肺动脉高压（PH）的儿童。所有患者均因ASD闭合手术前来就诊。在随访期间，他们的PH有所改善，右心房（RA）和右心室（RV）的大小恢复正常，术后一年所有患者的肺动脉压（PAP）均正常，RA和RV大小也正常。
根据我们的研究以及其他人的研究，ASD婴儿中PH的患病率较低，但当发现这种组合且无其他CHD时，应考虑进行ASD闭合手术。
