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过量用药后心肺骤停复苏后阿米替林及其代谢物的血浆浓度：一例报告。

Plasma concentration of amitriptyline and metabolites after resuscitation from cardiopulmonary arrest following an overdose: A case report.

作者信息

Ando Motozumi, Tamura Ryo, Nakasako Shinji, Takimoto Satsuki, Ariyoshi Koichi, Yamaguchi Marie, Sakizono Kenji, Eto Masaaki, Fukushima Shoji, Sugioka Nobuyuki, Hashida Tohru

机构信息

Faculty of Pharmaceutical Sciences Kobe Gakuin University Kobe Japan.

Present address: Department of Clinical Pharmacy and Sciences, School of Pharmacy Aichi Gakuin University Nagoya Japan.

出版信息

Clin Case Rep. 2020 Dec 15;9(2):805-811. doi: 10.1002/ccr3.3656. eCollection 2021 Feb.

DOI:10.1002/ccr3.3656
PMID:33598249
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7869369/
Abstract

It may need to pay attention to the sustention of moderate cardiotoxicity and delayed elevation of plasma 10-hydroxynortriptyline level in severe amitriptyline overdose case.

摘要

在严重阿米替林过量中毒病例中，可能需要注意维持适度的心脏毒性以及血浆10-羟基去甲替林水平的延迟升高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f330/7869369/55a1a2f01abe/CCR3-9-805-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f330/7869369/77bd8ac3bd52/CCR3-9-805-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f330/7869369/55a1a2f01abe/CCR3-9-805-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f330/7869369/77bd8ac3bd52/CCR3-9-805-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f330/7869369/55a1a2f01abe/CCR3-9-805-g002.jpg

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本文引用的文献

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Biomed Chromatogr. 2019 Dec;33(12):e4679. doi: 10.1002/bmc.4679. Epub 2019 Sep 8.
2
Delayed Cardiotoxicity From a Massive Nortriptyline Overdose Requiring Prolonged Treatment.大剂量去甲替林过量致延迟性心脏毒性，需长期治疗。
J Pharm Pract. 2020 Aug;33(4):543-547. doi: 10.1177/0897190019838700. Epub 2019 Apr 14.
3
MicroRNA-208a Regulates H9c2 Cells Simulated Ischemia-Reperfusion Myocardial Injury via Targeting CHD9 through Notch/NF-kappa B Signal Pathways.
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Int Heart J. 2018 May 30;59(3):580-588. doi: 10.1536/ihj.17-147. Epub 2018 May 20.
4
A Study on CYP2C19 and CYP2D6 Polymorphic Effects on Pharmacokinetics and Pharmacodynamics of Amitriptyline in Healthy Koreans.CYP2C19和CYP2D6基因多态性对健康韩国人阿米替林药代动力学和药效学影响的研究
Clin Transl Sci. 2017 Mar;10(2):93-101. doi: 10.1111/cts.12451. Epub 2017 Mar 14.
5
Pharmacodynamic interaction of green tea extract with hydrochlorothiazide against ischemia-reperfusion injury-induced myocardial infarction.绿茶提取物与氢氯噻嗪对缺血再灌注损伤诱导的心肌梗死的药效学相互作用。
J Adv Pharm Technol Res. 2014 Jul;5(3):134-9. doi: 10.4103/2231-4040.137428.
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Amitriptyline overdose in emergency department of university hospital: evaluation of 250 patients.大学医院急诊科三环类抗抑郁药阿米替林过量中毒：250例患者的评估
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7
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Br J Psychiatry. 2010 May;196(5):354-8. doi: 10.1192/bjp.bp.109.070219.
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