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柳氮磺胺吡啶诱导的药物超敏反应综合征（DRESS）后慢性持续性人疱疹病毒6B型（HHV-6B）感染，并在克罗恩样结肠炎中检测到HHV-6编码的小非编码RNA（sncRNAs）：病例报告

Chronic persistent HHV-6B infection after sulfasalazine-induced DRESS with demonstration of HHV-6 encoded small noncoding RNAs (sncRNAs) in Crohn's-like colitis: Case report.

作者信息

Descamps Vincent, Gautheret-Dejean Agnès, Pelletier Anne-Laure, Bonnafous Pascale, Deschamps Lydia, Prusty Bhupesh K

机构信息

Department of Dermatology Bichat Hospital APHP Paris Paris 7 University Paris France.

Department of Virology Pitié-Salpêtrière Hospital APHP Paris France.

出版信息

Clin Case Rep. 2020 Dec 18;9(2):841-844. doi: 10.1002/ccr3.3680. eCollection 2021 Feb.

DOI:10.1002/ccr3.3680
PMID:33598255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7869345/
Abstract

A sulfasalazine-induced DRESS (Drug Reactivation with Eosinophilia and Systemic Symptoms) was complicated by a Crohn's-like colitis. We demonstrated HHV-6 reactivation with presence of HHV-6 DNA and small noncoding RNA in colonic lesions. This observation confirms the major role of HHV-6 reactivation in DRESS manifestations and the importance of looking for HHV-6 reactivation in DRESS.

摘要

一例柳氮磺胺吡啶诱发的伴有嗜酸性粒细胞增多和全身症状的药物超敏反应综合征（DRESS）并发了克罗恩样结肠炎。我们在结肠病变中证实了人疱疹病毒6型（HHV-6）的再激活，同时存在HHV-6 DNA和小非编码RNA。这一观察结果证实了HHV-6再激活在DRESS表现中的主要作用以及在DRESS中寻找HHV-6再激活的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a420/7869345/4ae86244fd7f/CCR3-9-841-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a420/7869345/9113a7a461cf/CCR3-9-841-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a420/7869345/4ae86244fd7f/CCR3-9-841-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a420/7869345/9113a7a461cf/CCR3-9-841-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a420/7869345/4ae86244fd7f/CCR3-9-841-g002.jpg

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本文引用的文献

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Predominant Contribution of CD4 T Cells to Human Herpesvirus 6 (HHV-6) Load in the Peripheral Blood of Patients with Drug-induced Hypersensitivity Syndrome and Persistent HHV-6 Infection.药物性超敏反应综合征及持续性人疱疹病毒6型（HHV-6）感染患者外周血中CD4 T细胞对HHV-6载量的主要贡献
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Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study.
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): Focus on the Pathophysiological and Diagnostic Role of Viruses.
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Tissue specific signature of HHV-6 infection in ME/CFS.慢性疲劳综合征中HHV-6感染的组织特异性特征。
Front Mol Biosci. 2022 Dec 14;9:1044964. doi: 10.3389/fmolb.2022.1044964. eCollection 2022.
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The diagnosis of a DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations.基于典型的临床特征和病毒再激活，DRESS综合征的诊断已得到充分确立。
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