Carpentiere G, Castello F, Marino S
Institute of Medical Clinic, University of Palermo, Italy.
Chest. 1988 May;93(5):933-6. doi: 10.1378/chest.93.5.933.
To investigate the mechanisms contributing to refractoriness in exercise-induced asthma (EIA), airway responsiveness to histamine was studied in eight asthmatic patients. Patients were included in the study on the basis of their refractory response to multiple exercise challenges. Incremental challenges with inhaled histamine were performed at rest and 40 minutes after single and paired exercise tests. The geometric mean histamine concentration required to produce a 20 percent fall in FEV1 (PC20) for the challenge after paired exercise test (4.34 mg/ml) was significantly higher (p greater than 0.001) than those for the challenges after a single exercise (1.05 mg/ml) and for the challenge at rest (0.67 mg/ml). There was no significant difference between PC20 values at rest and after a single exercise test (p greater than 0.05). The results show that the response to histamine is reduced during the refractory period following paired exercise test.
为了研究运动诱发哮喘（EIA）难治性的机制，我们对8名哮喘患者的气道对组胺的反应性进行了研究。患者基于对多次运动激发试验的难治性反应被纳入研究。在静息状态以及单次和配对运动试验后40分钟，进行递增剂量的吸入组胺激发试验。配对运动试验后激发试验使第一秒用力呼气容积（FEV1）下降20%所需的组胺几何平均浓度（PC20）为4.34毫克/毫升，显著高于单次运动后激发试验的PC20（1.05毫克/毫升）以及静息状态下激发试验的PC20（0.67毫克/毫升）（p>0.001）。静息状态下和单次运动试验后的PC20值之间无显著差异（p>0.05）。结果表明，配对运动试验后的不应期内，对组胺的反应降低。
