Svanborg A
Department of Geriatric and Long-Term Care Medicine, University of Göteborg, Sweden.
Ciba Found Symp. 1988;134:3-16. doi: 10.1002/9780470513583.ch2.
In the longitudinal study of 70-year-olds in Göteborg the first age cohort (born 1901-1902) has now been followed for 15 years and the second cohort (born 1906-1907) for nine years; an intervention study has been added to the third age cohort (born 1911-1912). These longitudinal perspectives (derived from studies of samples shown to be representative of the total population) have successively improved the possibilities of distinguishing between ageing manifestations and symptoms caused by definable diseases. In addition to previously reported figures on the proportions of apparently healthy people at age 70 and 75, preliminary conclusions from the follow-up periods from age 79 indicate that at that age at least 20% do not suffer from symptoms of definable diseases. These findings have allowed detailed analyses to be made of the morphological and functional consequences of ageing as well as the calculation of clinical reference values for the age interval 70-79. The improving possibilities for distinguishing between ageing and morbidity have allowed certain conclusions to be drawn on obvious differences between age cohorts relating to the prevalence of disease and manifestations of ageing. These age-cohort differences could not be related to migration and ongoing genetic changes but there is indirect evidence for relationships to lifestyle and certain environmental factors. The reasons for these age-cohort differences in the manifestations of ageing are being analysed retrospectively through information on differences in living conditions between the cohorts and prospectively through the intervention programme (InterVention Elderly in Göteborg, IVEG).
在哥德堡对70岁老人的纵向研究中,第一个年龄组(出生于1901 - 1902年)现已随访了15年,第二个年龄组(出生于1906 - 1907年)随访了9年;对第三个年龄组(出生于1911 - 1912年)增加了一项干预研究。这些纵向研究视角(源自对经证明能代表总人口的样本的研究)已相继提高了区分衰老表现与可明确疾病所致症状的可能性。除了先前报告的70岁和75岁时明显健康人群的比例数据外,79岁随访期的初步结论表明,在该年龄至少20%的人没有可明确疾病的症状。这些发现使得能够对衰老的形态学和功能后果进行详细分析,并计算70 - 79岁年龄区间的临床参考值。区分衰老和发病的可能性不断提高,使得能够就年龄组在疾病患病率和衰老表现方面的明显差异得出某些结论。这些年龄组差异与移民和正在发生的基因变化无关,但有间接证据表明与生活方式和某些环境因素有关。目前正在通过回顾各年龄组生活条件差异的信息以及通过干预项目(哥德堡老年人干预项目,IVEG)前瞻性地分析这些年龄组在衰老表现方面存在差异的原因。