School of Nursing, University of Connecticut, Storrs, CT, USA.
Center for Advancement in Managing Pain, University of Connecticut, Storrs, CT, USA.
J Adv Nurs. 2021 May;77(5):2386-2397. doi: 10.1111/jan.14780. Epub 2021 Feb 17.
To assess associations among cannabis use, health-related quality of life, exercise, depression and sleep among a nationally representative sample of US adults living with cancer.
A cross-sectional correlational study.
We used survey data from the 2016-2018 Behavioral Risk Factor Surveillance System. Analyses were considered for sample weights and the complex designs. Logistic regression was performed to assess associations among cannabis use (0, 1-19, vs. 20-30 [frequent] days), health-related quality of life (0-13 vs. ≥14 mentally or physically unhealthy days in the past 30 days; 0-13 vs. ≥14 functionally limited days), exercise, depression, and sleep after accounting for covariates. Reason for cannabis use (medical vs. non-medical) was also assessed.
Frequent users had significantly more physically unhealthy days (adjusted odds ratio [OR]: 1.79, 95% CI: 1.28-2.51, p < .01) and reported ≥ 14 mentally unhealthy days (adjusted OR: 2.43, 95% CI: 1.78-3.32, p < .001) and depression (adjusted OR: 2.65, 95% CI: 1.97-3.57, p < .001) compared with non-users. A positive relationship between frequency of cannabis use and depression existed only among non-medical cannabis users.
Cancer survivors using cannabis frequently (20 days+ in the past month) had poorer mental health-related quality of life. The reason for cannabis use as well as frequency of use may be important considerations in predicting depression.
This is the first study that evaluates the associations among cannabis use, the purpose of cannabis use, HRQoL, exercise, depression and sleep in a nationally representative sample of US adults living with cancer. Frequent cannabis users are likely vulnerable to poorer mental health-related quality of life and depression, and non-medical cannabis use in frequent users was associated with depression. Given expanding medical cannabis legalization, these findings warrant further attention so that this information can be used by people living with cancer in decision-making for symptom self-management.
评估美国癌症患者中使用大麻与健康相关的生活质量、运动、抑郁和睡眠之间的关联。
横断面相关性研究。
我们使用了 2016-2018 年行为风险因素监测系统的调查数据。分析考虑了样本权重和复杂设计。使用逻辑回归评估了大麻使用情况（0、1-19 天与 20-30 天[频繁]天）、健康相关生活质量（0-13 天与过去 30 天内≥14 天身心不健康；0-13 天与≥14 天功能受限）、运动、抑郁和睡眠之间的关联，同时考虑了协变量。还评估了使用大麻的原因（医疗与非医疗）。
频繁使用者身心不健康的天数明显增多（调整后的优势比[OR]：1.79，95%CI：1.28-2.51，p<.01），并报告≥14 天心理不健康（调整后的 OR：2.43，95%CI：1.78-3.32，p<.001）和抑郁（调整后的 OR：2.65，95%CI：1.97-3.57，p<.001）天数比非使用者多。非医疗大麻使用者的大麻使用频率与抑郁之间存在正相关关系。
经常使用大麻（过去一个月使用 20 天以上）的癌症幸存者心理健康相关生活质量较差。大麻使用的原因和频率可能是预测抑郁的重要考虑因素。
这是第一项评估美国癌症患者中使用大麻、使用大麻的目的、健康相关生活质量、运动、抑郁和睡眠之间关联的全国代表性样本研究。频繁使用大麻的人可能更容易出现心理健康相关生活质量较差和抑郁的情况，而频繁使用非医用大麻与抑郁有关。鉴于医用大麻合法化的不断扩大，这些发现值得进一步关注，以便为癌症患者的自我症状管理决策提供这些信息。
