Medical College, Yan'an University, Yan'an 716000, People's Republic of China.
Biomed Mater. 2021 Feb 18;16(2):025004. doi: 10.1088/1748-605X/abdbdd.
A composite of hydroxyapatite (HA) and polymers prepared from amino acids and glycolic acid (PAG) was synthesized using an in situ melting polycondensation method. The in vitro degradability and bioactivity of the composite were evaluated, as well as its in vitro and in vivo biocompatibility based on subcutaneous and osseous implantation of samples in New Zealand white rabbits for 8 weeks. The results showed that the PAG/HA composite had higher degradability than PAG and showed a typical apatite morphology after immersion in simulated body fluid for 5 d. Both the PAG/HA composite and PAG alone showed excellent in vitro biocompatibility. In the rabbit model, PAG/HA composite could induce formation of new bone tissue after 4 weeks implantation, mainly owing to the excellent in vivo bioactivity of the implant. These results suggest that PAG/HA composites have the potential to guide bone regeneration and could be used as biodegradable biomaterials for bone repair.
采用原位熔融缩聚法合成了由氨基酸和乙二醇酸（PAG）制备的羟基磷灰石（HA）和聚合物的复合材料。通过对样品进行 8 周的新西兰白兔皮下和骨内植入，评估了复合材料的体外降解性和生物活性，以及其基于体外和体内的生物相容性。结果表明，PAG/HA 复合材料的降解性高于 PAG，并在模拟体液中浸泡 5 天后呈现典型的磷灰石形态。PAG/HA 复合材料和 PAG 单独均表现出优异的体外生物相容性。在兔模型中，PAG/HA 复合材料在植入 4 周后可诱导新骨组织形成，主要归因于植入物优异的体内生物活性。这些结果表明，PAG/HA 复合材料具有引导骨再生的潜力，可作为用于骨修复的可生物降解生物材料。
