形成具有受自然启发的环状缩肽配体的三（邻苯二酚）铁（III）配合物。
Formation of a tris(catecholato) iron(III) complex with a nature-inspired cyclic peptoid ligand.
机构信息
Department of Chemistry, School of Physics and Chemistry, Gwangju Institute of Science and Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju, 61005, Republic of Korea.
Western Seoul Center, Korea Basic Science Institute, University-Industry Cooperation Building, 150 Bukahyun-ro, Seodaemun-gu, Seoul, 120-140, Republic of Korea.
出版信息
Dalton Trans. 2021 Mar 16;50(10):3459-3463. doi: 10.1039/d1dt00091h.
Siderophore-mimicking macrocyclic peptoids were synthesized. Peptoid 3 with intramolecular hydrogen bonds showed an optimally arranged primary coordination sphere leading to a stable catecholate-iron complex. The tris(catecholato) structure of 3-Fe(iii) was determined with UV-vis, fluorescence, and EPR spectroscopies and DFT calculations. The iron binding affinity was comparable to that of deferoxamine, with enhanced stability upon air exposure.
合成了模拟铁载体的大环缩氨酸。具有分子内氢键的缩氨酸 3 呈现出最佳排列的初级配位球，形成稳定的儿茶酚-铁配合物。通过紫外可见光谱、荧光光谱和电子顺磁共振光谱以及 DFT 计算确定了 3-Fe(iii)的三（儿茶酚酸根）结构。铁结合亲和力可与去铁胺相媲美，并且在暴露于空气中时稳定性增强。
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