苯并吡喃-苯并吡喃羧酸PR-D-92-EA对过敏介质的体外拮抗作用。
In vitro antagonism of the mediators of allergy by a benzopyrano-benzopyran carboxylic acid PR-D-92-EA.
作者信息
Possanza G J, Bauen A, Stewart P B
出版信息
Int Arch Allergy Appl Immunol. 1975;49(6):789-95. doi: 10.1159/000231463.
PR-D-92-EA was tested on isolated guinea pig ileum and rat stomach strips for activity against mediators probably released after allergen antibody union. It antagonized the response produced by histamine, bradykinin, serotonin, prostaglandin E2, prostaglandin F2ALPHA and slow-reacting substance of anaphylaxis (SRS-A). The concentrations which blocked 50% of the response were 150, 145, 92, 70, 47, and 32 mug/ml, respectively. This compound may be useful in the treatment of allergic conditions.
PR-D-92-EA在离体豚鼠回肠和大鼠胃条上进行了测试，以检测其对过敏原抗体结合后可能释放的介质的活性。它拮抗组胺、缓激肽、5-羟色胺、前列腺素E2、前列腺素F2α和过敏反应慢反应物质（SRS-A）产生的反应。阻断50%反应的浓度分别为150、145、92、70、47和32微克/毫升。该化合物可能对治疗过敏状况有用。
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