Thomson A H, Miller S H, Green S T, Whiting B
Department of Materia Medica, University of Glasgow, Stobhill General Hospital, U.K.
Eur J Clin Pharmacol. 1988;34(1):47-50. doi: 10.1007/BF01061416.
The influence of food on the absorption characteristics of slow release isosorbide-5-mononitrate tablets was investigated in 10 normal healthy volunteers. There were no differences in the peak concentration achieved or the area under the curve, but the peak concentration occurred later when the drug was administered after food. The apparent elimination half-life ranged from 4.7 to 10.1 h. Bioavailability of slow-release isosorbide-5-mononitrate is therefore unaffected by food, but there is a slower rate of absorption.
在10名正常健康志愿者中研究了食物对缓释5-单硝酸异山梨酯片吸收特性的影响。所达到的峰浓度或曲线下面积没有差异，但在进食后给药时，峰浓度出现得较晚。表观消除半衰期为4.7至10.1小时。因此，食物不影响缓释5-单硝酸异山梨酯的生物利用度，但吸收速率较慢。
