Longmore J, Banjar W, Bradshaw C M, Szabadi E
Department of Psychiatry, University of Manchester, U.K.
Eur J Clin Pharmacol. 1988;34(1):97-9. doi: 10.1007/BF01061427.
Eight healthy male volunteers participated in four experimental sessions. In each session the subjects ingested a single dose of one of the following drugs: trazodone (controlled-release formulation), trazodone (conventional formulation), amitriptyline and placebo. Both trazodone and amitriptyline reduced subjectively rated alertness and increased digit cancellation time, and amitriptyline also reduced critical flicker fusion frequency. Both antidepressants reduced salivation, trazodone also caused miosis. There were no consistent differences between the effects of the two formulations of trazodone. The results of the psychological tests are indicative of the sedative properties of the antidepressants. It is likely that the reduction in salivation and pupil diameter by trazodone reflect alpha-adrenoceptor blockade, whereas the reduction in salivation by amitriptyline may be due to both cholinoceptor and alpha-adrenoceptor blockade.
八名健康男性志愿者参与了四个实验环节。在每个环节中，受试者服用以下药物中的一种单剂量药物：曲唑酮（缓释制剂）、曲唑酮（常规制剂）、阿米替林和安慰剂。曲唑酮和阿米替林均降低了主观评定的警觉性并延长了数字划消时间，且阿米替林还降低了临界闪烁融合频率。两种抗抑郁药均减少了唾液分泌，曲唑酮还导致了瞳孔缩小。曲唑酮两种制剂的效果之间没有一致的差异。心理测试结果表明了抗抑郁药的镇静特性。曲唑酮导致的唾液分泌和瞳孔直径减小可能反映了α-肾上腺素能受体阻滞，而阿米替林导致的唾液分泌减少可能是由于胆碱能受体和α-肾上腺素能受体阻滞共同作用的结果。
