Theofilopoulos N, Szabadi E, Bradshaw C M
Br J Clin Pharmacol. 1984 Aug;18(2):135-44. doi: 10.1111/j.1365-2125.1984.tb02445.x.
Eight healthy male volunteers participated in four experimental sessions in which they ingested one of the following drugs: ranitidine hydrochloride (150 mg), cimetidine hydrochloride (400 mg), thioridazine hydrochloride (50 mg), placebo (lactose). Drugs were allocated to subjects and sessions in a double-blind fashion, according to a balanced cross-over design. The subjects' mood state and psychomotor performance were assessed 1 and 3 h after drug taking. Mood state was measured using a battery of visual analogue scales, and psychomotor performance using pencil-and-paper tests, critical flicker fusion frequency, wire-maze tracing and tapping. Ranitidine and cimetidine had no significant effect on subjectively rated alertness, whereas thioridazine caused a significant decrease in alertness. Ranitidine and cimetidine had no significant effect on performance on the pencil-and-paper tests (digit cancellation, digit symbol substitution, symbol copying), whereas thioridazine caused a significant decrement on these tests. Ranitidine and cimetidine had no significant effect on critical flicker fusion frequency, wire-maze tracing, and tapping rate. Thioridazine caused a significant impairment of psychomotor performance as evidenced by all the instrumental tests. It is concluded that, in contrast to thioridazine and similarly to cimetidine, ranitidine has little effect on subjectively rated alertness and psychomotor performance in healthy volunteers.
八名健康男性志愿者参加了四个实验环节，在这些环节中他们分别服用了以下药物之一：盐酸雷尼替丁（150毫克）、盐酸西咪替丁（400毫克）、盐酸硫利达嗪（50毫克）、安慰剂（乳糖）。根据平衡交叉设计，药物以双盲方式分配给受试者和实验环节。在服药后1小时和3小时评估受试者的情绪状态和精神运动表现。情绪状态使用一系列视觉模拟量表进行测量，精神运动表现则通过纸笔测试、临界闪烁融合频率、线迷宫追踪和敲击测试来评估。雷尼替丁和西咪替丁对主观评定的警觉性没有显著影响，而硫利达嗪则导致警觉性显著下降。雷尼替丁和西咪替丁对纸笔测试（数字划消、数字符号替换、符号抄写）的表现没有显著影响，而硫利达嗪则导致这些测试的表现显著下降。雷尼替丁和西咪替丁对临界闪烁融合频率、线迷宫追踪和敲击速率没有显著影响。硫利达嗪导致精神运动表现显著受损，所有仪器测试均证明了这一点。结论是，与硫利达嗪不同，与西咪替丁相似，雷尼替丁对健康志愿者的主观评定警觉性和精神运动表现影响很小。
