The Competitive Aggregation Pathway of an Asymmetric Chiral Oligo(p-phenyleneethynylene) Towards the Formation of Individual P and M Supramolecular Helical Polymers.

A complex aggregation pathway towards two diastereomeric P and M supramolecular helices arises from the aggregation of a short, chiral, and rigid oligo(phenyleneethynylene) [OPE, (S)-1]. Thus, while Agg aggregate is obtained when a DCM solution of (S)-1 is diluted with MCH at room temperature, Agg aggregate is generated only after a slow heating (353 K)/cooling (273 K) process. Interestingly, during Agg formation (mechanism 1), short P chain oligomers are produced, which have a great tendency to aggregate in plane, yielding brick-like nanostructures that halt the aggregation process. On the other hand, after a heating/cooling cycle, long M type columnar helical aggregates (Agg ) are obtained, formed by individual supramolecular polymer chains (mechanism 2) easily visualized by AFM. The two different P/M orientations obtained for Agg and Agg reveal the dynamic character of the system and its ability to create diastereomeric helical structures under the right conditions. Different experimental protocols were explored to prepare long M type columnar helical aggregates, which are not obtained by using the previous MCH/DCM 99/1 (v/v) solvent mixture. The generation of the desired M oriented supramolecular polymer is achieved when toluene is added to the solvent mixture in a 97/2/1 MCH/Tol/DCM (v/v/v) ratio.