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ACE2 Elevation in Severe COVID-19.

作者信息

Reindl-Schwaighofer Roman, Hödlmoser Sebastian, Eskandary Farsad, Poglitsch Marko, Bonderman Diana, Strassl Robert, Aberle Judith H, Oberbauer Rainer, Zoufaly Alexander, Hecking Manfred

机构信息

Medical University of Vienna Vienna, Austria.

Attoquant Diagnostics Vienna, Austria and.

出版信息

Am J Respir Crit Care Med. 2021 May 1;203(9):1191-1196. doi: 10.1164/rccm.202101-0142LE.

DOI:10.1164/rccm.202101-0142LE
PMID:33600742
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8314901/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6272/8314901/70ee6b79b831/rccm.202101-0142LEf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6272/8314901/70ee6b79b831/rccm.202101-0142LEf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6272/8314901/70ee6b79b831/rccm.202101-0142LEf1.jpg

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本文引用的文献

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Lancet Respir Med. 2020 Nov;8(11):1154-1158. doi: 10.1016/S2213-2600(20)30418-5. Epub 2020 Sep 24.
2
A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm.涉及 RAS 介导的缓激肽风暴的 COVID-19 的机械模型和治疗干预。
Elife. 2020 Jul 7;9:e59177. doi: 10.7554/eLife.59177.
3
Equilibrium Angiotensin Metabolite Profiling in Patients with Acute Respiratory Distress Syndrome Indicates Angiotensin-Converting Enzyme Inhibition.
Angiotensin converting enzyme 2 in patients with sepsis associate with comorbidities but neither with mortality nor with organ failure.
脓毒症患者体内的血管紧张素转换酶2与合并症相关,但与死亡率和器官衰竭均无关。
Sci Rep. 2025 Apr 23;15(1):14198. doi: 10.1038/s41598-025-96640-0.
4
Alterations in the renin-angiotensin system during septic shock.脓毒性休克期间肾素-血管紧张素系统的改变。
Ann Intensive Care. 2025 Mar 24;15(1):40. doi: 10.1186/s13613-025-01463-x.
5
COVID-19 infection and pulmonary sarcoidosis: a systematic review and meta-analysis of morbidity, severity and mortality.新型冠状病毒肺炎感染与肺结节病:发病率、严重程度及死亡率的系统评价与荟萃分析
J Thorac Dis. 2025 Feb 28;17(2):744-752. doi: 10.21037/jtd-24-1620. Epub 2025 Feb 27.
6
The circulating renin-angiotensin system and mortality among patients hospitalized for COVID-19: a mechanistic substudy of the ACTIV-4 Host Tissue trials.新冠病毒疾病住院患者的循环肾素-血管紧张素系统与死亡率:ACTIV-4宿主组织试验的机制性亚研究
Am J Physiol Lung Cell Mol Physiol. 2025 Mar 1;328(3):L405-L412. doi: 10.1152/ajplung.00372.2024. Epub 2025 Jan 30.
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Renin-angiotensin-aldosterone system activation in plasma as marker for prognosis in critically ill patients with COVID-19: a prospective exploratory study.血浆肾素-血管紧张素-醛固酮系统激活作为COVID-19危重症患者预后的标志物:一项前瞻性探索性研究
Ann Intensive Care. 2025 Jan 16;15(1):10. doi: 10.1186/s13613-025-01433-3.
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急性呼吸窘迫综合征患者的平衡血管紧张素代谢物谱显示血管紧张素转换酶受到抑制。
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Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19.新型冠状病毒肺炎的肺血管内皮细胞炎症、血栓形成和血管生成。
N Engl J Med. 2020 Jul 9;383(2):120-128. doi: 10.1056/NEJMoa2015432. Epub 2020 May 21.
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Hypertension. 2019 Aug;74(2):285-294. doi: 10.1161/HYPERTENSIONAHA.119.12786. Epub 2019 Jun 24.
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Roles of Angiotensin Peptides and Recombinant Human ACE2 in Heart Failure.血管紧张素肽和重组人 ACE2 在心力衰竭中的作用。
J Am Coll Cardiol. 2017 Feb 21;69(7):805-819. doi: 10.1016/j.jacc.2016.11.064.
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Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections.血管紧张素转换酶2可预防致死性甲型H5N1禽流感感染。
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A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury.血管紧张素转换酶2(ACE2)在严重急性呼吸综合征冠状病毒诱导的肺损伤中的关键作用。
Nat Med. 2005 Aug;11(8):875-9. doi: 10.1038/nm1267. Epub 2005 Jul 10.