神经元羽状物引发扩布性去极化，这是驱动偏头痛和中风的电生理事件。
Neuronal plumes initiate spreading depolarization, the electrophysiologic event driving migraine and stroke.
机构信息
Department of Radiology, Massachusetts General Hospital, Boston, MA, USA.
出版信息
Neuron. 2021 Feb 17;109(4):563-565. doi: 10.1016/j.neuron.2021.01.024.
PMID:33600751
Abstract
In this issue of Neuron, Parker et al. discover neuronal plumes of glutamate release that initiate spreading depolarization, the electrophysiologic event underlying migraine. Mice with human migraine mutations express spontaneous and frequent plumes, which may explain the propensity to develop migraine attacks and the increased stroke risk in migraine-susceptible brains.
摘要
在本期《神经元》中，帕克等人发现了谷氨酸释放的神经元羽流，它引发了偏头痛的电生理事件——扩散性去极化。携带人类偏头痛突变的小鼠表现出自发和频繁的羽流，这可能解释了偏头痛易感性大脑中偏头痛发作的倾向和中风风险的增加。
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