人结膜杯状细胞中严重急性呼吸综合征冠状病毒 2 进入因子的高表达。
High expression of SARS-CoV-2 entry factors in human conjunctival goblet cells.
机构信息
Department of Ophthalmology, Fudan Eye & ENT Hospital, Shanghai, China; Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China.
BGI-Shenzhen, Shenzhen, 518083, China.
出版信息
Exp Eye Res. 2021 Apr;205:108501. doi: 10.1016/j.exer.2021.108501. Epub 2021 Feb 15.
The angiotensin-converting enzyme 2 (ACE2) receptor has been proved for SARS-CoV-2 cell entry after auxiliary cellular protease priming by transmembrane protease serine 2 (TMPRSS2), but the co-effect of this molecular mechanism was unknown. Here, single-cell sequencing was performed with human conjunctiva and the results have shown that ACE2 and TMPRSS2 were highly co-expressed in the goblet cells with genes involved in immunity process. This identification of conjunctival cell types which are permissive to virus entry would help to understand the process by which SARS-CoV-2 infection was established. These finding might be suggestive for COVID-19 control and protection.
血管紧张素转换酶 2（ACE2）受体已被证明可通过跨膜丝氨酸蛋白酶 2（TMPRSS2）辅助细胞蛋白酶进行 SARS-CoV-2 细胞进入，但该分子机制的共同作用尚不清楚。在这里，对人结膜进行了单细胞测序，结果表明 ACE2 和 TMPRSS2 在具有免疫过程相关基因的杯状细胞中高度共表达。这种对允许病毒进入的结膜细胞类型的鉴定将有助于了解 SARS-CoV-2 感染建立的过程。这些发现可能有助于 COVID-19 的控制和保护。
Zotero 插件