Maya-Maldonado Krystal, Cime-Castillo Jorge, Maya-Lucas Otoniel, Argotte-Ramos Rocio, Rodríguez Maria Carmen, Lanz-Mendoza Humberto
Centro de Investigaciones sobre Enfermedades Infecciosas. Instituto Nacional de Salud Pública, Av. Universidad 655, CP. 62100, Cuernavaca, Morelos, Mexico.
Novo Nordisk Foundation Center for Basic Metabolic Research. University of Copenhagen, Blegdamsvej 3B, DK-2200, Copenhagen, Denmark.
Dev Comp Immunol. 2021 Jul;120:104046. doi: 10.1016/j.dci.2021.104046. Epub 2021 Feb 15.
In invertebrates, "immunological priming" is considered as the ability to acquire a protective (adaptive) immune response against a pathogen due to previous exposure to the same organism. To date, the mechanism by which this type of adaptive immune response originates in insects is not well understood. In the Anopheles albimanus - Plasmodium berghei model, a DNA synthesis that probably indicates an endoreplication process during priming induction has been evidenced. This work aimed to know the transcriptomic profile in the midguts of An. albimanus after priming induction. Our analysis indicates the participation of regulatory elements of the cell cycle in the immunological priming and points out the importance of the cell cycle regulation in the mosquito midgut.
在无脊椎动物中，“免疫致敏”被认为是由于先前接触过同一病原体而获得针对该病原体的保护性（适应性）免疫反应的能力。迄今为止，这种适应性免疫反应在昆虫中产生的机制尚不清楚。在白纹伊蚊-伯氏疟原虫模型中，已经证实了一种可能表明致敏诱导过程中存在核内复制过程的DNA合成。这项工作旨在了解致敏诱导后白纹伊蚊中肠的转录组概况。我们的分析表明细胞周期调节元件参与了免疫致敏，并指出了细胞周期调节在蚊子中肠中的重要性。
