关于致癌性长链非编码 RNA OIP5-AS1 在人类恶性肿瘤中的作用的综述。
A review on the role of oncogenic lncRNA OIP5-AS1 in human malignancies.
机构信息
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
出版信息
Biomed Pharmacother. 2021 May;137:111366. doi: 10.1016/j.biopha.2021.111366. Epub 2021 Feb 15.
OIP5-AS1 is a long non-coding transcript with high expression in nervous system, but crucial functions in the neoplastic transformation. This lncRNA partake in the regulation of cell cycle transition at different points. Moreover, it acts a competing endogenous RNA for tens of microRNAs among them are miR-338-3p, miR-204-5p, miR-641, miR-422a, miR-367-3p, miR-153-3p, miR-186, miR-369-3p, miR-137, miR-342-3p, miR‑429, miR-3163, miR-363-3p, miR-186a-5p, hsa-miR-26a-3p, miR‑300, miR-217, miR-378a-3p and miR-448. OIP5-AS1 influence the carcinogenesis via different routes among them is modulation of epithelial-mesenchymal transition. Expression of OIP5-AS1 has been elevated in nearly all kinds of neoplastic tissues except for multiple myeloma. Moreover, in bladder, gastric cancer and lung cancers, assessment of its expression in clinical samples has led to conflicting results. In the current paper, we have provided a comprehensive collection of research papers that evaluated function of OIP5-AS1 in diverse cancer types.
OIP5-AS1 是一种在神经系统中高表达的长非编码转录本，但在肿瘤转化中具有关键功能。这种 lncRNA 参与了细胞周期转换的不同点的调节。此外，它作为数十种 microRNAs 的竞争性内源性 RNA 发挥作用，其中包括 miR-338-3p、miR-204-5p、miR-641、miR-422a、miR-367-3p、miR-153-3p、miR-186、miR-369-3p、miR-137、miR-342-3p、miR-429、miR-3163、miR-363-3p、miR-186a-5p、hsa-miR-26a-3p、miR-300、miR-217、miR-378a-3p 和 miR-448。OIP5-AS1 通过不同途径影响肿瘤发生，其中包括上皮-间充质转化的调节。除多发性骨髓瘤外，几乎所有类型的肿瘤组织中 OIP5-AS1 的表达都升高了。此外，在膀胱癌、胃癌和肺癌中，对其在临床样本中的表达评估导致了相互矛盾的结果。在本文中，我们提供了一份全面的研究论文集合，评估了 OIP5-AS1 在不同癌症类型中的功能。
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