细胞中的 Gq-Gi-PLCβ：远不止其重构部分的总和。
Gq-Gi-PLCβ in cells: More than the sum of its reconstituted parts.
机构信息
Department of Pharmacology, UT Southwestern Medical Center, 6001 Forest Park Drive, Dallas, TX 75390, USA; Cancer Discovery Team, Wilkie Laboratory, Department of Pharmacology, UT Southwestern Medical Center, 6001 Forest Park Drive, Dallas, TX 75390, USA.
Department of Pharmacology, UT Southwestern Medical Center, 6001 Forest Park Drive, Dallas, TX 75390, USA; Cancer Discovery Team, Wilkie Laboratory, Department of Pharmacology, UT Southwestern Medical Center, 6001 Forest Park Drive, Dallas, TX 75390, USA.
出版信息
Cell Calcium. 2021 Mar;94:102340. doi: 10.1016/j.ceca.2020.102340. Epub 2021 Jan 18.
The recent paper by Pfeil et al., "Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs", opens another path from biochemical in vitro reconstitution to understanding the complex regulation of calcium signaling inside the cell.
最近，Pfeil 等人发表的论文“三聚体 G 蛋白亚基 Gαq 是 Gi 偶联 GPCR 介导的 Gβγ 诱导钙动员的主开关”，为从生化体外重构到理解细胞内钙信号复杂调节的研究开辟了另一条途径。
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