The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China,
Chemotherapy. 2021;66(1-2):40-46. doi: 10.1159/000513058. Epub 2021 Feb 18.
The aim of this study was to evaluate the prognostic value of the albumin-to-alkaline phosphatase ratio (AAPR) in patients with nonmetastatic nasopharyngeal carcinoma (NPC).
Patients with nonmetastatic NPC who underwent chemoradiotherapy (CRT) were retrospectively analyzed. The AAPR was calculated using the last value of albumin to alkaline phosphatase that was measured within 1 week before CRT. The optimal cutoff value for the AAPR value was determined by an X-tile plot. Propensity score matching (PSM) was performed to balance the differences of the baseline characteristics. The Kaplan-Meier method and log-rank test were used to calculate the survival. A Cox proportional hazards regression model was conducted for the multivariate analysis.
Totally, 87 patients with nonmetastatic NPC who underwent CRT were included in the analysis. The optimal cutoff level for the AAPR was 0.46. The group with an AAPR ≤0.46 was more likely to have poorer overall survival (OS), progression-free survival (PFS), and distant metastasis-free survival (DMFS) (p = 0.023, p = 0.031 and p = 0.027, for OS, PFS, and DMFS, respectively). In Cox proportional hazards analysis, high AAPR was a better prognostic predictor.
AAPR may be a reliable prognostic index for nonmetastatic NPC patients.
本研究旨在评估白蛋白-碱性磷酸酶比值（AAPR）在非转移性鼻咽癌（NPC）患者中的预后价值。
回顾性分析接受放化疗（CRT）的非转移性 NPC 患者。AAPR 是通过 CRT 前 1 周内最后一次白蛋白与碱性磷酸酶的测量值计算得出的。采用 X-tile 图确定 AAPR 值的最佳截断值。采用倾向评分匹配（PSM）来平衡基线特征的差异。采用 Kaplan-Meier 方法和对数秩检验计算生存情况。采用 Cox 比例风险回归模型进行多因素分析。
共纳入 87 例接受 CRT 的非转移性 NPC 患者进行分析。AAPR 的最佳截断值为 0.46。AAPR≤0.46 组的总生存期（OS）、无进展生存期（PFS）和无远处转移生存期（DMFS）更差（p=0.023、p=0.031 和 p=0.027，分别用于 OS、PFS 和 DMFS）。Cox 比例风险分析显示，高 AAPR 是更好的预后预测指标。
AAPR 可能是预测非转移性 NPC 患者预后的可靠指标。
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