Legagneux V, Dubois M F, Morange M, Bensaude O
Groupe de Biologie Moléculaire du Stress, Institut Pasteur, Paris, France.
FEBS Lett. 1988 Apr 25;231(2):417-20. doi: 10.1016/0014-5793(88)80862-7.
The 90 kDa heat shock protein (hsp 90) is a major phosphorylated protein under normal growth conditions. However, it does not incorporate detectable levels of phosphate by incubation of control HeLa cell lysates with [gamma-32P]ATP in vitro. In this paper we show that strong phosphorylation of hsp 90 occurs in lysates prepared from heat shocked HeLa cells. Possible involvement of the eukaryotic initiation factor 2 kinase of the heme-controlled repressor of translation is discussed.
