Department of Biochemistry All India Institute of Medical Sciences Delhi Ansari Nagar, ,India.
Department of Internal Medicine All India Institute of Medical Sciences Jodhpur Basni phase 2, Jodhpur, ,India.
Infect Disord Drug Targets. 2021;21(8):e160921191570. doi: 10.2174/1871526521666210218202226.
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus, which is a cause of the ongoing pandemic, has the potential to infect the nervous system and cause neurological manifestations. However, patients with primarily neurological symptoms are often overlooked, therefore, they are being tested later.
We aim to summarize all the neurological manifestations that have been reported so far, to aid in early diagnosis and prevent further complications of the disease.
We did a literature search on the topic through Google Scholar, PubMed, and WHO resources by keywords, including coronavirus, SARS-CoV-2, COVID-19, clinical features, stroke, transverse myelitis, encephalitis, encephalopathy, Guillain-Barre syndrome, hypogeusia, hyposmia, anosmia, and neurological manifestations.
SARS-CoV-2 can affect the neuronal cells by both direct and indirect mechanisms. This can lead to various neurological manifestations ranging from subtle symptoms of myalgia, headache, dizziness, hypogeusia, hyposmia to dreaded complications like stroke, encephalitis, demyelinating disease like Guillain-Barre syndrome.
Presentation of COVID-19 with neurological features is not uncommon, and these patients should be tested earlier to help in the prevention of transmission, early diagnosis, and management.
导致当前大流行的严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）病毒有可能感染神经系统并引起神经表现。然而，常因主要表现为神经系统症状而被忽视，从而导致这些患者就诊较晚。
我们旨在总结迄今为止报告的所有神经系统表现，以帮助早期诊断并预防疾病的进一步并发症。
我们通过关键词在 Google Scholar、PubMed 和世界卫生组织资源上进行了相关主题的文献检索，包括冠状病毒、SARS-CoV-2、COVID-19、临床特征、中风、横贯性脊髓炎、脑炎、脑病、吉兰-巴雷综合征、味觉减退、嗅觉减退、嗅觉缺失和神经表现。
SARS-CoV-2 可通过直接和间接机制影响神经元细胞，从而导致各种神经系统表现，从轻微的肌痛、头痛、头晕、味觉减退、嗅觉减退到可怕的并发症，如中风、脑炎、脱髓鞘疾病如吉兰-巴雷综合征。
以神经系统表现为特征的 COVID-19 并不少见，这些患者应尽早接受检测，以帮助预防传播、早期诊断和管理。
