在治疗尿路上皮癌方面的恩福妥单抗的概况：迄今为止的证据。
Profile of Enfortumab Vedotin in the Treatment of Urothelial Carcinoma: The Evidence to Date.
机构信息
Department of Urology, Al Zahraa Hospital, University Medical Center, Lebanese University, Beirut, Lebanon.
2nd Department of Urology, School of Medicine, Sismanoglio Hospital, National and Kapodistrian University of Athens, Athens, Greece.
出版信息
Drug Des Devel Ther. 2021 Feb 11;15:453-462. doi: 10.2147/DDDT.S240854. eCollection 2021.
Abstract
Nowadays the therapeutic landscape for advanced and metastatic urothelial carcinoma continues to evolve. The recent regulatory approval of enfortumab vedotin (EV) for the treatment of advanced urothelial cancer confirms the evolving role of antibody-drug conjugates. EV demonstrates a favorable profile in heavily pretreated patients with locally advanced or metastatic urothelial carcinoma. Early survival reports demonstrate a significant antitumor effectiveness along with a rather acceptable safety profile in a difficult-to-treat population.
摘要
如今，晚期和转移性尿路上皮癌的治疗格局仍在不断发展。最近，恩福妥珠单抗（EV）获批用于治疗晚期尿路上皮癌，这证实了抗体药物偶联物的作用不断演变。EV 在晚期或转移性局部进展性尿路上皮癌的大量预处理患者中显示出良好的疗效。早期生存报告表明，在治疗困难的人群中，该药具有显著的抗肿瘤疗效和可接受的安全性。
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