严重经痛期间血压和血管变化的营养调节
Nutritional modulation of blood pressure and vascular changes during severe menstrual cramps.
作者信息
Njoku Uche C, Amadi Peter U, Amadi Joy A
机构信息
Department of Biochemistry, University of Port Harcourt, Choba, Rivers State, Nigeria.
Department of Biochemistry, Imo State University Owerri, Imo State, Nigeria.
出版信息
J Taibah Univ Med Sci. 2020 Nov 27;16(1):93-101. doi: 10.1016/j.jtumed.2020.10.018. eCollection 2021 Feb.
OBJECTIVES
This study examined the influence of nutrition on the severity of menstrual pains and associated transient changes in blood pressure (BP) and vascular-health indicators. It has also investigated the influence of nutrition on angiotensin (ANG II) and vascular cell adhesion molecules (VCAM-1).
METHODS
A total of 207 university students, aged between 18 and 25 years, were grouped into three groups: a no-dysmenorrhoea (control) group, a moderate dysmenorrhoea (MDys) group, and a severe dysmenorrhoea (SDys) group, using the NRS-11 scale and initial contactin-1 (CNTN-1) levels. The groups were separately fed vegetable, protein, and carbohydrate meals. The meal plan involved three different types of food served three times a day (for breakfast, lunch, and dinner), beginning 48 h before menstruation.
RESULTS
We found that 73.9% and 100% of the MDys patients on the protein and carbohydrate diets, respectively, had severe dysmenorrhoea. As many as 69.6% of the SDys patients on vegetable diets experienced no dysmenorrhoea; the BP of 61% of SDys normalised to the standard values of 120/80. The BP of 87% MDys had systolic BP ≥ 130 and ≥90 diastolic BP after carbohydrate meals. On the other hand, 30% of SDys had higher BP after protein meals. With respect to the choice of food, the severity of menstrual pain was positively correlated with ANG II (r = 0.5158) and VCAM-1 (r = 0.5849). ANG-II. Similarly, VCAM-1 were significantly elevated ( < 0.05) in the dysmenorrhoeal participants. The mean VCAM-1 and ANG-II levels of dysmenorrhoeal participants placed on vegetable meals were comparable to the control baseline levels.
CONCLUSIONS
This study recommends the intake of a vegetable meal at least 48 h before menstruation as an effective nutritional approach to preventing and managing severe menstrual cramps. This approach can also prevent associated vascular changes. Carbohydrate meals should be avoided at least 48 h before menstruation.
目的
本研究探讨营养对痛经严重程度以及血压（BP）和血管健康指标相关短暂变化的影响。还研究了营养对血管紧张素（ANG II）和血管细胞粘附分子（VCAM - 1）的影响。
方法
总共207名年龄在18至25岁之间的大学生，使用NRS - 11量表和初始接触蛋白 - 1（CNTN - 1）水平分为三组：无痛经（对照组）、中度痛经（MDys）组和重度痛经（SDys）组。这些组分别食用蔬菜餐、蛋白质餐和碳水化合物餐。饮食计划包括从月经前48小时开始，每天三次提供三种不同类型的食物（早餐、午餐和晚餐）。
结果
我们发现，分别采用蛋白质和碳水化合物饮食的MDys患者中，73.9%和100%有严重痛经。采用蔬菜饮食的SDys患者中多达69.6%没有痛经；61%的SDys患者血压恢复到120/80的标准值。碳水化合物餐后，87%的MDys患者收缩压≥130且舒张压≥90。另一方面，30%的SDys患者在蛋白质餐后血压升高。关于食物选择，痛经严重程度与ANG II（r = 0.5158）和VCAM - 1（r = 0.5849）呈正相关。ANG - II也是如此。同样，痛经参与者的VCAM - 1显著升高（P < 0.05）。食用蔬菜餐的痛经参与者的平均VCAM - 1和ANG - II水平与对照基线水平相当。
结论
本研究建议在月经前至少48小时食用蔬菜餐，作为预防和管理严重月经痉挛的有效营养方法。这种方法还可以预防相关的血管变化。月经前至少48小时应避免食用碳水化合物餐。
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