Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland.
Front Immunol. 2021 Feb 2;11:604529. doi: 10.3389/fimmu.2020.604529. eCollection 2020.
Enterovirus and adenovirus infections have been linked to the development of celiac disease. We evaluated this association in children who developed biopsy-proven celiac disease (N = 41) during prospective observation starting from birth, and in control children (N = 53) matched for the calendar time of birth, sex, and HLA-DQ genotype. Enterovirus and adenovirus infections were diagnosed by seroconversions in virus antibodies in longitudinally collected sera using EIA. Enterovirus infections were more frequent in case children before the appearance of celiac disease-associated tissue transglutaminase autoantibodies compared to the corresponding period in control children (OR 6.3, 95% CI 1.8-22.3; p = 0.005). No difference was observed in the frequency of adenovirus infections. The findings suggest that enterovirus infections may contribute to the process leading to celiac disease.
肠道病毒和腺病毒感染与乳糜泻的发生有关。我们评估了在前瞻性观察中从出生开始就发展为活检证实的乳糜泻的儿童（N=41）和匹配出生时间、性别和 HLA-DQ 基因型的对照组儿童（N=53）中这种关联。通过使用 EIA 在纵向采集的血清中检测病毒抗体的血清转化来诊断肠道病毒和腺病毒感染。与对照组儿童相对应的时期相比，在出现乳糜泻相关组织转谷氨酰胺酶自身抗体之前，病例儿童中肠道病毒感染更为频繁（OR 6.3，95%CI 1.8-22.3；p=0.005）。腺病毒感染的频率没有差异。这些发现表明肠道病毒感染可能有助于导致乳糜泻的过程。
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