Kelishadi Roya, Barekatain Behzad, Fatahi Atefeh
Department of Pediatrics, School of Medicine, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Pediatrics, Division of Neonatology, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Int J Pediatr. 2021 Feb 1;2021:8893754. doi: 10.1155/2021/8893754. eCollection 2021.
Deficiency or reduced transmission of long-chain fatty acids and essential fatty acids may inhibit lung growth and development. We aimed to evaluate and compare serum triglyceride and cholesterol levels in premature neonates with RDS.
This study is a cross-sectional study performed on premature neonates born in Beheshti Hospital in Isfahan in 2018. Immediately after birth and after umbilical cord clumping, blood samples were taken from the umbilical artery and triglyceride and total cholesterol levels were measured. Those patients with the diagnosis of RDS were transferred to the neonatal intensive care unit (NICU). Data regarding the laboratory results of the lipid profile in patients were compared to that in the other group.
A total number of 100 neonates entered the study and were divided into 2 groups. Analysis of gender and mean gestational ages among the two groups showed no significant differences between the groups ( = 0.84 and = 0.28, respectively). Further analysis showed a significant decreased serum cholesterol in the group 1 of patients ( = 0.01), but there were no significant differences between the two groups regarding triglyceride levels ( = 0.43). There was a significant direct relationship between gestational age and serum triglyceride levels in patients with RDS ( = 0.550, < 0.001).
Here, we indicated significantly lower cholesterol levels in the cord serum of premature neonates with RDS compared to non-RDS premature neonates. Our data also showed a significant direct relationship between gestational age and serum triglyceride levels in patients with RDS. These data were in line with the previous studies.
长链脂肪酸和必需脂肪酸的缺乏或转运减少可能会抑制肺的生长和发育。我们旨在评估和比较患有呼吸窘迫综合征（RDS）的早产儿的血清甘油三酯和胆固醇水平。
本研究是一项横断面研究，对2018年在伊斯法罕的贝赫什提医院出生的早产儿进行。出生后立即并在脐带结扎后，从脐动脉采集血样，测量甘油三酯和总胆固醇水平。那些被诊断为RDS的患者被转入新生儿重症监护病房（NICU）。将患者血脂谱的实验室结果数据与另一组进行比较。
共有100名新生儿进入研究并被分为两组。两组之间的性别和平均胎龄分析显示两组之间无显著差异（分别为 = 0.84和 = 0.28）。进一步分析显示，第1组患者的血清胆固醇显著降低（ = 0.01），但两组之间的甘油三酯水平无显著差异（ = 0.43）。RDS患者的胎龄与血清甘油三酯水平之间存在显著的正相关（ = 0.550， < 0.001）。
在此，我们指出与非RDS早产儿相比，患有RDS的早产儿脐带血清中的胆固醇水平显著降低。我们的数据还显示，RDS患者的胎龄与血清甘油三酯水平之间存在显著的正相关。这些数据与先前的研究一致。
