Reiss Jonathan D, Mataraso Samson J, Holzapfel Lindsay F, Marić Ivana, Kasowski Maya M, Martin Camilia R, Long Jonathan Z, Stevenson David K, Shaw Gary M
Department of Pediatrics, Division of Neonatology, Stanford University School of Medicine, Palo Alto, California.
Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California.
Neoreviews. 2025 Feb 1;26(2):e100-e114. doi: 10.1542/neo.26-2-011.
The metabolome and lipidome comprise the thousands of molecular compounds in an organism. Molecular compounds consist of the upstream metabolic components of intracellular reactions or the byproducts of cellular pathways. Molecular and biochemical perturbations are associated with disorders in newborns and infants. The diagnosis of inborn errors of metabolism has relied on targeted metabolomics for several decades. Newer approaches offer the potential to identify novel biomarkers for common diseases of the newborn and infant. They may also elucidate novel predictive or diagnostic measures for a variety of health trajectories. Here, we review the relevance of the metabolome and lipidome for common disorders and highlight challenges and opportunities for future investigations.
代谢组和脂质组包含生物体内数千种分子化合物。分子化合物由细胞内反应的上游代谢成分或细胞途径的副产物组成。分子和生化扰动与新生儿和婴儿的疾病有关。几十年来，先天性代谢缺陷的诊断一直依赖于靶向代谢组学。新方法有可能识别新生儿和婴儿常见疾病的新型生物标志物。它们还可能阐明各种健康轨迹的新型预测或诊断措施。在此，我们综述代谢组和脂质组与常见疾病的相关性，并强调未来研究的挑战和机遇。
