Chen Hong, Tian Aijun, Wu Yixiang, Li Rongrong, Han Ruijuan, Xu Xiaowei, Cheng Sumian
Department of Glaucoma, Hebei Eye Hospital, Xingtai, Hebei 054000, P.R. China.
Department of Fundus Disease, Hebei Eye Hospital, Xingtai, Hebei 054000, P.R. China.
Exp Ther Med. 2021 Mar;21(3):253. doi: 10.3892/etm.2021.9683. Epub 2021 Jan 25.
The present study aimed to explore the clinical role of heat shock protein 70 (HSP70) in patients with acute angle-closure glaucoma (AACG). Seventy-four AACG patients who were admitted to our hospital from April 2017 to April 2019 were enrolled as a study group (SG). A further 70 healthy people undergoing physical examinations during the same period were enrolled as a control group (CG). HSP70 concentration was compared between the two groups, and the clinical value of this protein in AACG was analyzed. HSP70 concentration in SG was significantly lower than that in CG (P<0.050). The sensitivity and specificity of HSP70 for diagnosing AACG were 79.73 and 74.29%, respectively (P<0.001). HSP70 concentration was positively correlated with central anterior chamber depth and peripheral anterior chamber depth, but negatively correlated with anterior angle and intraocular pressure (P<0.001). HSP70 had a relatively satisfactory predictive value for adverse reactions during the treatment (P<0.001). HSP70 concentration was markedly reduced in AACG patients, and its detection had a relatively satisfactory predictive value for AACG. Thus, HSP70 may be a potential and notable indicator for diagnosing and treating glaucoma in the future.
本研究旨在探讨热休克蛋白70（HSP70）在急性闭角型青光眼（AACG）患者中的临床作用。选取2017年4月至2019年4月我院收治的74例AACG患者作为研究组（SG）。同期另选取70例接受体检的健康人作为对照组（CG）。比较两组HSP70浓度，并分析该蛋白在AACG中的临床价值。研究组HSP70浓度显著低于对照组（P<0.050）。HSP70诊断AACG的敏感度和特异度分别为79.73%和74.29%（P<0.001）。HSP70浓度与中央前房深度和周边前房深度呈正相关，但与前房角和眼压呈负相关（P<0.001）。HSP70对治疗期间的不良反应具有相对满意的预测价值（P<0.001）。AACG患者HSP70浓度明显降低，其检测对AACG具有相对满意的预测价值。因此，HSP70可能是未来诊断和治疗青光眼的一个潜在且显著的指标。
