Liu Weixi, Yang Zhicheng, Chen Yan, Yang Haoyu, Wan Xiaoxian, Zhou Xindie, Liu Ruiping, Zhang Yunkun
Department of Orthopaedics, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China.
Front Med (Lausanne). 2021 Feb 2;8:598076. doi: 10.3389/fmed.2021.598076. eCollection 2021.
Rheumatoid arthritis (RA) is related to several pivotal susceptibility genes, including and genes. Although the connection between polymorphisms of and genes in different populations of RA have been studied extensively, the results are controversial. To clarify the correlation in the Chinese Han population between , and gene polymorphisms, and RA susceptibility. A case-control study (574 RA patients and 804 controls) was conducted to determine the correlation between rs231775 and rs16840252 gene polymorphisms, rs17281995 gene polymorphisms, and the risk of RA for the Chinese Han population. Furthermore, an additional meta-analysis, including three single nucleotide polymorphisms (SNPs) ( rs231775, rs3087243, and rs5742909) from 32 citations, including 43 studies, 24,703 cases and 23,825 controls was performed to elucidate the relationship between known SNPs in the genes and RA for more robust conclusions. The results showed that rs231775 gene polymorphism decreased the RA risk (GA vs. AA, OR = 0.77, = 0.025), whereas rs16840252 and rs17281995 gene polymorphisms were not related to RA susceptibility. Stratification analyses by RF, ACPA, CRP, ESR, DAS28, and functional class identified significant associations for rs231775 and rs16840252 gene polymorphisms in the RF-positive and RF-negative groups. A meta-analysis of the literature on gene polymorphisms and RA risk revealed that the risk of RA was decreased by rs231775 gene polymorphisms. The rs231775 gene polymorphism decreased the risk of RA, whereas rs16840252 and rs17281995 gene polymorphisms were not related to RA risk. A meta-analysis indicated that rs231775 and rs3087243 gene polymorphisms decreased the risk of RA. To support these analytical results, additional clinical cases should be investigated in further studies.
类风湿关节炎（RA）与多个关键易感基因相关，包括[具体基因1]和[具体基因2]基因。尽管已对不同人群中[具体基因1]和[具体基因2]基因多态性之间的联系进行了广泛研究，但结果存在争议。为阐明中国汉族人群中[具体基因1]、[具体基因2]基因多态性与RA易感性之间的相关性。开展了一项病例对照研究（574例RA患者和804例对照），以确定[具体基因1] rs231775和rs16840252基因多态性、[具体基因2] rs17281995基因多态性与中国汉族人群RA风险之间的相关性。此外，进行了一项额外的荟萃分析，纳入来自32篇文献、包括43项研究、24703例病例和23825例对照的三个单核苷酸多态性（SNP）（[具体基因1] rs231775、[具体基因2] rs3087243和[具体基因2] rs5742909），以阐明[具体基因2]基因中已知SNP与RA之间的关系，从而得出更可靠的结论。结果显示，[具体基因1] rs231775基因多态性降低了RA风险（GA与AA相比，OR = 0.77，P = 0.025），而[具体基因1] rs16840252和[具体基因2] rs17281995基因多态性与RA易感性无关。按类风湿因子（RF）、抗环瓜氨酸肽抗体（ACPA）、C反应蛋白（CRP）、红细胞沉降率（ESR）、疾病活动评分28（DAS28）和功能分级进行分层分析，发现[具体基因1] rs231775和rs16840252基因多态性在RF阳性和RF阴性组中有显著关联。对[具体基因2]基因多态性与RA风险的文献进行荟萃分析表明，[具体基因1] rs231775基因多态性降低了RA风险。[具体基因1] rs231775基因多态性降低了RA风险，而[具体基因1] rs16840252和[具体基因2] rs17281995基因多态性与RA风险无关。荟萃分析表明，[具体基因1] rs231775和rs3087243基因多态性降低了RA风险。为支持这些分析结果，应在进一步研究中调查更多临床病例。
