Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Neurourol Urodyn. 2021 Mar;40(3):763-770. doi: 10.1002/nau.24630. Epub 2021 Feb 19.
Interstitial cystitis (IC) is a chronic pain syndrome that is characterized by suprapubic pain upon bladder filling. Bletilla striata, a well-known traditional Chinese herb with established efficacy in wound healing and anti-inflammation, was hypothesized to improve the symptoms of IC possibly though forming a physical barrier that could isolate the bladder tissue from irritants. This study was conducted to evaluate the beneficial effects of intravesical treatment with B. striata extract solution (BSES) on visceral pain and bladder function of rats with zymosan-induced IC.
Thirty female rats were randomly divided into control group, zymosan-induced cystitis rats treated with normal saline (Z + NS), and zymosan-induced cystitis rats treated with BSES (Z + BSES). All rats underwent evaluation for abdominal withdrawal reflex (AWR) scores to assess visceral hypersensitivity, cystometrography, and electromyogram (EMG) of both external urethral sphincter and bladder detrusor. Data were analyzed by one way analysis of variance.
The Z + NS group had an increased visceral hypersensitivity as compared to control group. Rats treated with BSES (Z + BSES group) had decreased AWR scores and amplitude of bladder detrusor-EMG. Besides, BSES treatment improved overactive bladder with significant effects on the extend of micturition interval and increase of storage of urine.
Intravesical instillation of BSES can significantly alleviate zymosan-induced visceral hypersensitivity and bladder overactivity associated with IC. This study suggested that intravesical instillation with BSES might be a promising treatment for IC.
间质性膀胱炎（IC）是一种以膀胱充盈时耻骨上疼痛为特征的慢性疼痛综合征。白及，一种具有良好疗效的传统中药，在伤口愈合和抗炎方面已得到证实，据推测可以通过形成物理屏障，将膀胱组织与刺激物隔离开来，从而改善 IC 的症状。本研究旨在评估白及提取物溶液（BSES）膀胱内治疗对酵母聚糖诱导的 IC 大鼠内脏痛觉和膀胱功能的有益作用。
30 只雌性大鼠随机分为对照组、生理盐水处理的酵母聚糖诱导膀胱炎大鼠（Z+NS 组）和 BSES 处理的酵母聚糖诱导膀胱炎大鼠（Z+BSES 组）。所有大鼠均进行腹壁退缩反射（AWR）评分评估内脏敏感性、尿动力学和尿道外括约肌和膀胱逼尿肌肌电图（EMG）检测。采用单因素方差分析进行数据分析。
与对照组相比，Z+NS 组大鼠内脏敏感性增加。与 Z+NS 组相比，BSES 治疗组（Z+BSES 组）大鼠 AWR 评分和膀胱逼尿肌 EMG 幅度降低。此外，BSES 治疗改善了膀胱过度活动，对排尿间隔延长和储尿增加有显著作用。
BSES 膀胱内灌注可显著减轻酵母聚糖诱导的内脏敏感性和与 IC 相关的膀胱过度活动。本研究表明，BSES 膀胱内灌注可能是治疗 IC 的一种有前途的方法。
