Division of Developmental Biology, Department of Pediatrics; Division of Plastic Surgery, Department of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Shriners Hospital, Cincinnati, Ohio, USA.
Dev Dyn. 2021 Sep;250(9):1358-1367. doi: 10.1002/dvdy.318. Epub 2021 Mar 1.
The naturally occurring chicken mutant talpid (ta ), best known for its limb and craniofacial defects, has long served as a valuable tool for developmental biologists studying growth and patterning of craniofacial structures and the limb. The mutant provides a unique tool to examine the molecular and cellular processes regulating limb development.
This mutant also provides unique insights into the evolution of developmental genetic programs. Previous work defined the appearance of atavistic dentition in ta embryos. Herein we describe the appearance of ancestral characters of the hindlimb in embryonic ta chicken embryos.
As the ta phenotype arises as a result of mutation in C2CD3 and disrupted cilia function, this mutant provides genetic and developmental insight into the causes of asymmetry in the limb and also a model for the evolution of the avian hindlimb.
天然发生的鸡突变体 talpid（ta），以其肢体和颅面缺陷而闻名，长期以来一直是发育生物学家研究颅面结构和肢体生长和模式形成的宝贵工具。该突变体提供了一个独特的工具来检查调节肢体发育的分子和细胞过程。
该突变体也为发育遗传程序的进化提供了独特的见解。以前的工作定义了 ta 胚胎中返祖牙的出现。本文描述了 ta 鸡胚胎中后肢的祖先特征的出现。
由于 ta 表型是由于 C2CD3 突变和纤毛功能障碍引起的，因此该突变体为肢体不对称的原因提供了遗传和发育方面的见解，也是鸟类后肢进化的模型。
