DNA-PK 的屈伸动作：在 DNA 上跳舞。
The plié by DNA-PK: dancing on DNA.
机构信息
Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
出版信息
Mol Cell. 2021 Feb 18;81(4):644-646. doi: 10.1016/j.molcel.2021.01.025.
PMID:33606972
Abstract
In this issue of Molecular Cell, Chen et al. (2020) report the structural transition during DNA-dependent activation of DNA-PK, shedding light on the mechanism by which kinase inhibitors and auto-phosphorylation-deficient DNA-PKcs compromise non-homologous end-joining (Chen et al., 2020).
摘要
在本期《分子细胞》中，Chen 等人（2020 年）报道了 DNA 依赖性激活 DNA-PK 过程中的结构转变，揭示了激酶抑制剂和自身磷酸化缺陷的 DNA-PKcs 如何破坏非同源末端连接的机制（Chen 等人，2020 年）。
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