Department of Oriental Neuropsychiatry, College of Korean Medicine, Dong-eui University, Busan.
Department of Gastroenterology, College of Korean Medicine, Kyung Hee University, Seoul.
Medicine (Baltimore). 2021 Feb 19;100(7):e24403. doi: 10.1097/MD.0000000000024403.
Functional dyspepsia (FD) is a common functional gastrointestinal disease with a high prevalence. However, due to the limitations of conventional Western treatments, such as acid suppressants, prokinetics, Helicobacter pylori eradication treatment, and antidepressants, the popularity of complementary and alternative medicine, such as acupuncture, is steadily increasing. We describe the methods that will be used to evaluate the effectiveness and safety of acupuncture as add-on therapies to conventional Western medications in patients with FD.
A total of 12 English, Korean, and Chinese electronic databases will be searched by 2 researchers from their inception dates to December 2020. Randomized controlled trials assessing the effectiveness and safety of acupuncture as add-on therapies to conventional Western medications in patients with FD will be included. The primary outcome measure will be the symptom score of FD, and secondary outcome measures will be total effective rate, quality of life, level of gut peptide hormones, incidence of adverse events, and recurrence rate. Data analysis will be performed using the Review Manager version 5.3. The risk of bias of the included studies and the quality of evidence for the main findings will be evaluated using the Cochrane Collaborations risk of bias tool and the Grading of Recommendations Assessment, Development, and Evaluation approach, respectively.
The findings of this review will provide evidence on the complementary effectiveness and safety of acupuncture for FD for clinicians, patients, and policy makers in decision making.
DOI 10.17605/OSF.IO/MXREN (https://osf.io/mxren).
功能性消化不良（FD）是一种常见的功能性胃肠道疾病，其患病率较高。然而，由于传统的西医疗法（如抑酸剂、促动力药、幽门螺杆菌根除治疗和抗抑郁药）存在局限性，补充和替代医学（如针灸）的应用日益广泛。我们将描述评估针灸作为 FD 患者的常规西药辅助治疗的有效性和安全性的方法。
研究人员将从各数据库建立日期至 2020 年 12 月，对 12 个英文、韩文和中文电子数据库进行全面检索。纳入评估针灸作为 FD 患者的常规西药辅助治疗的有效性和安全性的随机对照试验。主要结局指标将是 FD 的症状评分，次要结局指标将是总有效率、生活质量、肠道肽激素水平、不良事件发生率和复发率。将使用 Review Manager 版本 5.3 进行数据分析。将使用 Cochrane 协作风险偏倚工具评估纳入研究的偏倚风险和主要发现的证据质量，并使用 Grading of Recommendations Assessment, Development, and Evaluation 方法进行评估。
本综述的结果将为临床医生、患者和决策者在决策中提供针灸治疗 FD 的补充有效性和安全性证据。
OSF 注册号：DOI 10.17605/OSF.IO/MXREN（https://osf.io/mxren）。
