Post Graduate Programa in Rehabilitation Sciences, Universidade Nove de Julho - UNINOVE, São Paulo, SP, 01525-000, Brazil.
Graduate Program in Rehabilitation Sciences, Department of Physical Therapy, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, 31270-901, Brazil.
BMC Pulm Med. 2021 Feb 19;21(1):61. doi: 10.1186/s12890-020-01355-9.
Inflammation caused by chronic lung disease in childhood may lead to delayed heart rate recovery (HRR) however, there is lack of evidence on HRR in this population. The aim was to assess HRR after functional capacity testing in asthmatic children and adolescents and to compare with severity and disease control.
This was a study secondary to a randomized control trial. The modified shuttle test (MST) was performed to assess functional capacity and HRR. This is an externally cadenced test in which the distance walked is the outcome. HRR was assessed after MST and was defined as HR at exercise peak minus HR in the second minute after the end of exercise. Asthma control was assessed by the Asthma Control Test (ACT). Data normality was tested by Shapiro Wilk and the comparison between groups was made by Student's t test or Mann Whitney test for numerical variables, and by Chi-square test for categorical variables. Statistical significance was considered when p < 0.05. SPSS version 20 was used in the analyzes.
The sample included 77 patients diagnosed with asthma (asthma group - AG) who were regularly treated for asthma. Control group (CG) consisted of 44 volunteers considered healthy, matched in age and gender to AG. The median age of CG was 12 (10-14) years and in AG 11 (9-13 years) being classified as mild to moderate asthmatic, and 57% of the sample had controlled asthma by ACT. Distance walked in the CG was 952 ± 286 m and AG 799 ± 313 m, p = 0.001. HRR was more efficient in CG (79 ± 15 bpm) compared to AG (69 ± 12 bpm), p = 0.001. The mild (69 ± 12 beats) and severe (72 ± 15 beats) AG presented worse HRR compared to control group (79 ± 15 bpm), p < 0.05.
Asthmatic children and adolescents have delayed HRR after modified Shuttle test compared to their peers, suggesting that asthma leads to autonomic nervous system imbalance.
Registered in Clinical Trials under number NCT02383069 and approved by the Universidade Nove de Julho - UNINOVE Research Ethics Committee, protocol number 738192/2014.
儿童慢性肺部疾病引起的炎症可能导致心率恢复（HRR）延迟，然而，关于该人群的 HRR 缺乏证据。目的是评估哮喘儿童和青少年在进行功能能力测试后的 HRR，并与严重程度和疾病控制进行比较。
这是一项随机对照试验的二次研究。采用改良 shuttle 测试（MST）评估功能能力和 HRR。这是一种外部节拍测试，其中行走的距离是结果。HRR 在 MST 后进行评估，定义为运动峰值时的 HR 减去运动结束后第 2 分钟时的 HR。哮喘控制通过哮喘控制测试（ACT）进行评估。通过 Shapiro-Wilk 检验测试数据正态性，通过学生 t 检验或 Mann-Whitney 检验比较数值变量，通过卡方检验比较分类变量。当 p<0.05 时认为具有统计学意义。分析使用 SPSS 版本 20。
该样本包括 77 名被诊断为哮喘的患者（哮喘组 - AG），他们定期接受哮喘治疗。对照组（CG）由 44 名被认为健康的志愿者组成，在年龄和性别上与 AG 相匹配。CG 的中位年龄为 12（10-14）岁，AG 为 11（9-13 岁），被归类为轻度至中度哮喘，57%的样本通过 ACT 控制了哮喘。CG 的行走距离为 952±286m，AG 为 799±313m，p=0.001。CG 的 HRR 更有效（79±15bpm），而 AG 为（69±12bpm），p=0.001。轻度（69±12 次）和重度（72±15 次）AG 的 HRR 比对照组（79±15bpm）更差，p<0.05。
与同龄人相比，哮喘儿童和青少年在改良 shuttle 测试后 HRR 延迟，表明哮喘导致自主神经系统失衡。
在临床试验中注册，编号为 NCT02383069，并获得了诺维诺伊九大学 - UNINOVE 研究伦理委员会的批准，编号为 738192/2014。
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