Siak Jessica, Flint Nir, Shmueli Hezzy G, Siegel Robert J, Rader Florian
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif.
Department of Cardiology, Tel Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Israel.
Am J Med. 2021 Jun;134(6):735-744.e1. doi: 10.1016/j.amjmed.2021.01.019. Epub 2021 Feb 17.
The medicinal properties of colchicine have been recognized for centuries. Although previously used for gout and familial Mediterranean fever, its immune-modulating, anti-inflammatory, and antifibrotic effects are increasingly recognized as beneficial in the treatment of cardiovascular disorders. In this systematic review, we summarize the current evidence on colchicine's effectiveness in 1) pericarditis, 2) coronary artery disease, and 3) atrial fibrillation. We also discuss the safety, potential adverse effects, and common drug interactions that should be considered during use.
几个世纪以来，秋水仙碱的药用特性已为人所知。尽管它以前用于治疗痛风和家族性地中海热，但其免疫调节、抗炎和抗纤维化作用在心血管疾病治疗中的益处日益得到认可。在本系统评价中，我们总结了关于秋水仙碱在以下方面有效性的现有证据：1）心包炎，2）冠状动脉疾病，3）心房颤动。我们还讨论了使用过程中应考虑的安全性、潜在不良反应和常见药物相互作用。
