Zeng Tian, Guan Yang, Li Yu-Kun, Wu Qing, Tang Xiao-Jun, Zeng Xin, Ling Hui, Zou Juan
Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, University of South China, Hengyang, Hunan 421001, PR China.
Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330000, PR China.
Clin Chim Acta. 2021 Jun;517:92-98. doi: 10.1016/j.cca.2021.02.005. Epub 2021 Feb 18.
MCM6 is a significant DNA replication regulator that plays a crucial role in sustaining the cell cycle. In many cancer cells, MCM6 expression is enhanced. For example, persistently increased expression of MCM6 promotes the formation, development and progression of hepatocellular carcinoma (HCC). Up- and down-regulation studies have indicated that MCM6 regulates cell cycle, proliferation, metastasis, immune response and the maintenance of the DNA replication system. MCM6 can also regulate downstream signaling such as MEK/ERK thus promoting carcinogenesis. Accordingly, MCM6 may represent a sensitive and specific biomarker to predict adverse progression and poor outcome. Furthermore, inhibition of MCM6 may be an effective cancer treatment. The present review summarizes the latest results on the inactivating and activating functions of MCM6, underlining its function in carcinogenesis. Further studies of the carcinogenic functions of MCM6 may provide novel insight into cancer biology and shed light on new approaches for cancer diagnosis and treatment.
MCM6是一种重要的DNA复制调节因子，在维持细胞周期中起着关键作用。在许多癌细胞中，MCM6的表达会增强。例如，MCM6持续上调的表达促进肝细胞癌（HCC）的形成、发展和进展。上调和下调研究表明，MCM6调节细胞周期、增殖、转移、免疫反应以及DNA复制系统的维持。MCM6还可以调节下游信号，如MEK/ERK，从而促进肿瘤发生。因此，MCM6可能是预测不良进展和不良预后的敏感且特异的生物标志物。此外，抑制MCM6可能是一种有效的癌症治疗方法。本综述总结了关于MCM6失活和激活功能的最新研究结果，强调了其在肿瘤发生中的作用。对MCM6致癌功能的进一步研究可能为癌症生物学提供新的见解，并为癌症诊断和治疗的新方法提供思路。
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