Lana-Peixoto Marco A, Talim Natália C, Pedrosa Denison, Macedo Jéssica Marques, Santiago-Amaral Juliana
CIEM MS Research Center, Federal University of Minas Gerais Medical School, Belo Horizonte, Brazil.
CIEM MS Research Center, Federal University of Minas Gerais Medical School, Belo Horizonte, Brazil.
Mult Scler Relat Disord. 2021 May;50:102807. doi: 10.1016/j.msard.2021.102807. Epub 2021 Feb 3.
Studies on the prevalence of neuromyelitis optica spectrum disorder (NMOSD) are still scarce. The aim of the current study was to determine the prevalence rate of NMOSD in Belo Horizonte, southeast Brazil, where the prevalence rate of multiple sclerosis (MS) has already been established.
For this observational study, eligible patients had to meet the 2015 International Panel for Neuromyelitis Optica Diagnosis, be seen at the study center between January 2000 and February 2019 and live in Belo Horizonte. The prevalence rate of NMOSD was estimated based on the number of MS and NMOSD patients seen at same Center during the same period, and the previously established prevalence of MS in Belo Horizonte.
During the study period, there were 69 patients with NMOSD, 60 (87.0%) of whom were females, and 44 (63.8%) non-whites. The median age at disease onset was 36.7 (4-72) years, the mean EDSS score 4.78±2.36, and the mean ARR 0.57±0.43. Anti-aquaporin-4 immunoglobulin testing was available for 61 (88.4%) patients, of whom 41 (67.2%) had a positive result. During the same period, 280 MS patients were seen. Considering the local known prevalence rate of MS of 18.1/100,000 inhabitants, the estimated NMOSD prevalence rate in Belo Horizonte was 4.52/100,000 (95% CI 3.72-5.43) inhabitants.
The prevalence rate of NMOSD in Belo Horizonte is high as compared with those found in most of the studies reported to date.
视神经脊髓炎谱系障碍（NMOSD）患病率的研究仍然较少。本研究的目的是确定巴西东南部贝洛奥里藏特市NMOSD的患病率，该市多发性硬化症（MS）的患病率已确定。
对于这项观察性研究，符合条件的患者必须符合2015年视神经脊髓炎国际诊断小组标准，于2000年1月至2019年2月期间在研究中心就诊且居住在贝洛奥里藏特市。基于同期在同一中心就诊的MS和NMOSD患者数量以及贝洛奥里藏特市先前确定的MS患病率，估计NMOSD的患病率。
在研究期间，有69例NMOSD患者，其中60例（87.0%）为女性，44例（63.8%）为非白人。疾病发病的中位年龄为36.7（4 - 72）岁，平均扩展残疾状态量表（EDSS）评分为4.78±2.36，平均年复发率（ARR）为0.57±0.43。61例（88.4%）患者进行了抗水通道蛋白4免疫球蛋白检测，其中41例（67.2%）结果呈阳性。同期，共诊治了280例MS患者。考虑到当地已知的MS患病率为18.1/10万居民，贝洛奥里藏特市NMOSD的估计患病率为4.52/10万（95%可信区间3.72 - 5.43）居民。
与迄今报道的大多数研究相比，贝洛奥里藏特市NMOSD的患病率较高。
