Applied Neuroscience Research Group, Central European Institute of Technology - CEITEC, Masaryk University, Brno, Czech Republic; Faculty of Medicine, Masaryk University, Brno, Czech Republic; Surgeon General Office of the Slovak Armed Forces, Ružomberok, Slovak Republic.
Department of Telecommunications, Brno University of Technology, Brno, Czech Republic.
Parkinsonism Relat Disord. 2021 Mar;84:122-128. doi: 10.1016/j.parkreldis.2021.02.012. Epub 2021 Feb 9.
Hypokinetic dysarthria (HD) is common in Parkinson's disease (PD). Our objective was to evaluate articulatory networks and their reorganization due to PD pathology in individuals without overt speech impairment using a multimodal MRI protocol and acoustic analysis of speech.
A total of 34 PD patients with no subjective HD complaints and 25 age-matched healthy controls (HC) underwent speech task recordings, structural MRI, and reading task-induced and resting-state fMRI. Grey matter probability maps, task-induced activations, and resting-state functional connectivity within the regions engaged in speech production (ROIs) were assessed and compared between groups. Correlation with acoustic parameters was also performed.
PD patients as compared Tto HC displayed temporal decreases in speech loudness which were related to BOLD signal increases in the right-sided regions of the dorsal language pathway/articulatory network. Among those regions, activation of the right anterior cingulate was increased in PD as compared to HC. We also found bilateral posterior superior temporal gyrus (STG) GM loss in PD as compared to HC that was strongly associated with diadochokinetic (DDK) irregularity in the PD group. Task-induced activations of the left STG were increased in PD as compared to HC and were related to the DDK rate control.
The results provide insight into the neural correlates of speech production control and distinct articulatory network reorganization in PD apparent already in patients without subjective speech impairment.
运动障碍性构音障碍（HD）在帕金森病（PD）中很常见。我们的目的是使用多模态 MRI 方案和语音声学分析，评估无明显言语障碍的 PD 患者的发音网络及其因 PD 病理而导致的重组。
共有 34 名 PD 患者和 25 名年龄匹配的健康对照者（HC）接受了语音任务记录、结构 MRI 以及阅读任务诱导和静息状态 fMRI。评估并比较了两组之间的灰质概率图、任务诱导激活和参与言语产生的区域（ROI）的静息状态功能连接。还与声学参数进行了相关性分析。
与 HC 相比，PD 患者的言语响度呈现出时间上的下降，这与右侧语言通路/发音网络区域的 BOLD 信号增加有关。在这些区域中，与 HC 相比，PD 患者的右侧前扣带活动增加。与 HC 相比，我们还发现 PD 患者双侧后上颞叶（STG）GM 损失，与 PD 组的双音节词速率不规则性有很强的关联。与 HC 相比，PD 患者的左 STG 任务诱导激活增加，与 DDK 速率控制有关。
这些结果提供了关于言语产生控制和 PD 中明显的发音网络重组的神经相关性的深入了解，这些在没有主观言语障碍的患者中已经存在。
