Banwinkler Magdalena, Theis Hendrik, Prange Stéphane, van Eimeren Thilo
Multimodal Neuroimaging Group, Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
Brain Sci. 2022 Sep 15;12(9):1248. doi: 10.3390/brainsci12091248.
The limbic system describes a complex of brain structures central for memory, learning, as well as goal directed and emotional behavior. In addition to pathological studies, recent findings using in vivo structural and functional imaging of the brain pinpoint the vulnerability of limbic structures to neurodegeneration in Parkinson's disease (PD) throughout the disease course. Accordingly, dysfunction of the limbic system is critically related to the symptom complex which characterizes PD, including neuropsychiatric, vegetative, and motor symptoms, and their heterogeneity in patients with PD. The aim of this systematic review was to put the spotlight on neuroimaging of the limbic system in PD and to give an overview of the most important structures affected by the disease, their function, disease related alterations, and corresponding clinical manifestations. PubMed was searched in order to identify the most recent studies that investigate the limbic system in PD with the help of neuroimaging methods. First, PD related neuropathological changes and corresponding clinical symptoms of each limbic system region are reviewed, and, finally, a network integration of the limbic system within the complex of PD pathology is discussed.
边缘系统是指一组脑结构复合体，对记忆、学习以及目标导向和情感行为至关重要。除了病理学研究外，近期利用大脑活体结构和功能成像的研究结果表明，在帕金森病（PD）的整个病程中，边缘结构易发生神经退行性变。因此，边缘系统功能障碍与PD的症状复合体密切相关，这些症状包括神经精神症状、自主神经症状和运动症状，以及PD患者症状的异质性。本系统评价的目的是聚焦于PD患者边缘系统的神经影像学研究，并概述受该疾病影响的最重要结构、它们的功能、与疾病相关的改变以及相应的临床表现。通过检索PubMed以确定利用神经影像学方法研究PD患者边缘系统的最新研究。首先，回顾与PD相关的神经病理学变化以及边缘系统各区域相应的临床症状，最后讨论边缘系统在PD病理复合体中的网络整合。
