肢端肥大症的治愈标准：活跃期与非活跃期肢端肥大症患者基础生长激素和血浆生长调节素C浓度的比较

Criteria for the cure of acromegaly: comparison between basal growth hormone and somatomedin C plasma concentrations in active and non-active acromegalic patients.

作者信息

Giannella-Neto D, Wajchenberg B L, Mendonça B B, Almeida S F, Macchione M, Spencer E M

机构信息

Hospital das Clínicas, University of São Paulo School of Medicine, Brazil.

出版信息

J Endocrinol Invest. 1988 Jan;11(1):57-60. doi: 10.1007/BF03350100.

DOI:10.1007/BF03350100

PMID:3361077

Abstract

Fasting plasma growth hormone (GH) and somatomedin C (SmC) levels were compared as criteria for the cure of acromegaly in 7 untreated and 16 treated acromegalic patients studied 1 to 16 yr after pituitary surgery and/or radiotherapy. The patients without active disease presented a significant correlation between GH and SmC. Only when basal GH was lower than 2.5 ng/ml were SmC values within the normal range. The subjects with active acromegaly (both treated and untreated) presenting GH higher than 5 ng/ml did not show any correlation between GH and SmC levels.

摘要

对7例未经治疗和16例经治疗的肢端肥大症患者进行了研究，在垂体手术和/或放疗后1至16年，比较了空腹血浆生长激素（GH）和生长调节素C（SmC）水平，以此作为肢端肥大症治愈的标准。无活动性疾病的患者中，GH和SmC之间存在显著相关性。仅当基础GH低于2.5 ng/ml时，SmC值才在正常范围内。患有活动性肢端肥大症的患者（包括经治疗和未经治疗的），若GH高于5 ng/ml，则GH和SmC水平之间无任何相关性。