Tucker H S, Grubb S R, Wigand J P, Watlington C O, Blackard W G, Becker D P
Arch Intern Med. 1980 Jun;140(6):795-802.
Pituitary tumors were removed transsphenoidally in 32 patients with acromegaly. Ten patients had high prolactin (PL) levels as well as elevated growth hormone (GH) levels. In 24 patients, GH levels were lowered to 5 ng/mL or less and remained low. The PL level was reduced to normal in eight patients. Of three patients with postoperative GH levels of 6 to 10 ng/mL, one patient remains in this range but two have relapsed. Five patients showed only a partial lowering in GH level. Pituitary irradiation lowered the level further. Hypopituitarism developed in four patients. Permanent diabetes insipidus occurred in one patient and meningitis developed in another. They subsequently recovered. There were no deaths. Abnormal GH responses to hyperglycemia, hypoglycemia, and levodopa returned to normal following surgery. Transsphenoidal tumor removal appears to be an effective treatment for acromegaly.
32例肢端肥大症患者经蝶窦切除垂体肿瘤。10例患者催乳素（PL）水平高，生长激素（GH）水平也升高。24例患者的GH水平降至5 ng/mL或更低并维持在低水平。8例患者的PL水平降至正常。术后GH水平为6至10 ng/mL的3例患者中，1例仍处于该范围，但2例复发。5例患者的GH水平仅部分降低。垂体放疗使水平进一步降低。4例患者发生垂体功能减退。1例患者出现永久性尿崩症，另1例发生脑膜炎。他们随后康复。无死亡病例。术后对高血糖、低血糖和左旋多巴的异常GH反应恢复正常。经蝶窦肿瘤切除似乎是肢端肥大症的有效治疗方法。
