Kostić Milan, Korićanac Goran, Tepavčević Snežana, Stanišić Jelena, Romić Snježana, Ćulafić Tijana, Ivković Tamara, Stojiljković Mojca
Department for Molecular Biology and Endocrinology, "Vinča" Institute of Nuclear Sciences - National Institute of thе Republic of Serbia, University of Belgrade, Belgrade, Serbia.
Arch Physiol Biochem. 2023 Dec;129(4):922-932. doi: 10.1080/13813455.2021.1886118. Epub 2021 Feb 21.
Excessive fructose consumption causes ectopic lipid storage leading to metabolic disorders and cardiovascular diseases associated with defective substrate utilisation in the heart.
Examining the preventive impact of low-intensity exercise on alterations related to fructose-rich diet (FRD) on cardiac fatty acid (FA) transport and metabolism.
Male Wistar rats were divided into control and two groups that received 10% fructose for 9 weeks, one of which was additionally exposed to exercise.
FRD elevated plasma and cardiac TAG, FATP1 in plasma membrane, Lipin 1 in microsomes and HSL mRNA, while mitochondrial CPT1 was decreased. Exercise decreased plasma free FA level, raised CD36 in plasma membrane and FATP1 in lysate, mitochondrial CPT1 and decreased microsomal Lipin 1 in fructose-fed rats.
FRD changed plasma lipids and augmented partitioning of FA to TAG storage in the heart, whereas exercise in FRD rats switched metabolism of FA towards β-oxidation.
过量摄入果糖会导致异位脂质储存，引发代谢紊乱和心血管疾病，这与心脏中底物利用缺陷有关。
研究低强度运动对富含果糖饮食（FRD）引起的心脏脂肪酸（FA）转运和代谢改变的预防作用。
将雄性Wistar大鼠分为对照组和两组，后两组给予10%果糖，持续9周，其中一组额外进行运动。
FRD使血浆和心脏甘油三酯（TAG）、质膜上的脂肪酸转运蛋白1（FATP1）、微粒体中的脂肪酶1（Lipin 1）和激素敏感性脂肪酶（HSL）mRNA升高，而线粒体肉碱棕榈酰转移酶1（CPT1）降低。运动降低了果糖喂养大鼠的血浆游离脂肪酸水平，提高了质膜上的脂肪酸转运蛋白CD36和裂解物中的FATP1、线粒体CPT1，并降低了微粒体Lipin 1。
FRD改变了血浆脂质，增加了心脏中FA向TAG储存的分配，而FRD大鼠的运动使FA代谢转向β-氧化。
