激光间质内热疗治疗 SRS 后局部复发性脑转移瘤的疗效：系统评价和荟萃分析。
The efficacy of laser interstitial thermal therapy for brain metastases with in-field recurrence following SRS: systemic review and meta-analysis.
机构信息
Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China.
Department of Health Statistics, Second Military Medical University, Shanghai, China.
出版信息
Int J Hyperthermia. 2021;38(1):273-281. doi: 10.1080/02656736.2021.1889696.
OBJECTIVE
To study the efficacy of LITT for BM patients experiencing in-field recurrence following SRS.
METHODS
A literature search was conducted to identify studies investigating local control (LC) rate and overall survival (OS) of LITT for BMs with IFR following SRS.
RESULTS
Analysis included 14 studies (470 patients with 542 lesions). The 6-month (LC-6) and 12-month (LC-12) local control rates were 78.5% (95% CI: 70.6-84.8%) and 69.0% (95% CI: 60.0-76.7%) separately. Pooled median OS was 17.15 months (95% CI: 13.27-24.8). The overall OS-6 and OS-12 rates were 76.0% (95% CI: 71.4-80.0%) and 63.4% (95% CI: 52.9-72.7%) separately. LITT provided more favorable local control efficacy in RN than BM recurrence (LC-6: 87.4% vs. 67.9%, = 0.009; LC-12: 76.3% vs. 59.9%, = 0.041).
CONCLUSIONS
LITT is an effective treatment for BM patients experiencing IFR following SRS. For different pathological entities, LITT showed more satisfactory local control efficacy on RN than BM recurrence.
目的
研究 LITT 治疗 SRS 后发生场内复发的脑转移瘤（BM）患者的疗效。
方法
检索文献，以确定评估 LITT 治疗 SRS 后发生场内复发的 BM 患者局部控制率（LC）和总生存率（OS）的研究。
结果
分析纳入 14 项研究（470 例患者 542 个病灶）。6 个月（LC-6）和 12 个月（LC-12）的局部控制率分别为 78.5%（95%CI：70.6-84.8%）和 69.0%（95%CI：60.0-76.7%）。汇总的中位 OS 为 17.15 个月（95%CI：13.27-24.8）。整体 OS-6 和 OS-12 率分别为 76.0%（95%CI：71.4-80.0%）和 63.4%（95%CI：52.9-72.7%）。LITT 在 RN 中的局部控制效果优于 BM 复发（LC-6：87.4%比 67.9%，=0.009；LC-12：76.3%比 59.9%，=0.041）。
结论
LITT 是 SRS 后发生场内复发的 BM 患者的有效治疗方法。对于不同的病理实体，LITT 在 RN 中的局部控制效果优于 BM 复发。
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